PMID: 16628012Apr 22, 2006Paper

E2F1 and telomerase: alliance in the dark side

Cell Cycle
Marta M AlonsoCandelaria Gomez-Manzano

Abstract

Cancer arises from a stepwise accumulation of genetic changes. Among these changes, deregulation of the Rb/E2F1 pathway and constitutively active telomerase are pivotal milestones for the attainment of immortality and maintaining the neoplastic phenotype. We recently showed the Rb/E2F1 pathway to be a direct modulator of telomerase activity in normal and cancer cells, specifically in malignant gliomas. In addition, we reported that the correlation between the levels of expression of E2F1 and hTERT -the catalytic subunit of telomerase- in a subset of patients with glioblastoma multiforme confers clinical relevance to the role of E2F1 in triggering or maintaining hTERT expression. Here we review the evidence supporting the mechanistic linkage between E2F1 and telomerase activation. We also consider the clinical implications of this association in terms of prognostic significance and opportunities for the development of new and more rational therapeutic strategies.

Citations

Dec 31, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Yafei ZhangDianchun Fang
May 20, 2009·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Alpana KumariJai Dev Wig
Jan 28, 2015·Journal of Medical Genetics·Massimo ManginoAbraham Aviv
Oct 29, 2011·Mutation Research·Catherine Cifuentes-Rojas, Dorothy E Shippen
Mar 13, 2008·Cancer Letters·Marta M AlonsoCandelaria Gomez-Manzano
Apr 7, 2017·Carcinogenesis·Hongliang LiuUNKNOWN Transdisciplinary Research in Cancer of the Lung (TRICL) Research Team
Mar 4, 2020·Cancers·Nalini SrinivasRajiv Kumar

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