PMID: 8963896Mar 1, 1996Paper

Ea recombinational hot spot in the mouse major histocompatibility complex maps to the fourth intron of the Ea gene

Genome Research
S KhambataH C Passmore

Abstract

The majority of recombination events detected within the mouse major histocompatibility complex (MHC) fall into regions of limited physical distance known as hot spots of meiotic recombination. The hot spot associated with the Ea gene appears to be active only in the presence of the p allele carried by the intra-MHC recombinant strain BIO.F(13R). To study the frequency, regulation, and haplotype specificity of recombination at the Ea hot spot, progeny from three different backcrosses involving BIO.F(13R) were screened for recombination events across the MHC using DNA microsatellite markers. Screening of a total of 750 backcross progeny permitted the identification of seven recombinants within the Ea gene. Using restriction site polymorphisms, and sequence-based nucleotide polymorphisms, the recombination breakpoints in all seven Ea recombinants were mapped to two adjacent segments of 71 bp and 346 bp in intron 4 of the Ea gene.

References

Jun 1, 1992·Current Opinion in Cell Biology·J E Haber
Jan 1, 1992·Mammalian Genome : Official Journal of the International Mammalian Genome Society·E C BrydaH C Passmore
Feb 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·A ChakravartiM A Permutt
Jun 1, 1986·The Journal of Experimental Medicine·W P LafuseC S David
Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Mar 1, 1983·Cell·D J MathisH O McDevitt
Oct 1, 1993·Current Opinion in Genetics & Development·C L Atcheson, R E Esposito

❮ Previous
Next ❯

Citations

Jun 29, 2000·Immunology Today·R J AllcockP Price
Sep 6, 2003·Trends in Genetics : TIG·Bernard de Massy
Jun 1, 2004·Molecular and Cellular Biology·K T NishantM R S Rao
Dec 14, 2007·Annual Review of Genetics·Norman ArnheimIrene Tiemann-Boege
Feb 20, 2009·PLoS Biology·Corinne GreyBernard de Massy
Jun 26, 2007·PLoS Genetics·Frédéric Baudat, Bernard de Massy
Mar 19, 2016·DNA Repair·Prosenjit PaulSupriyo Chakraborty

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.