Eagle Effect in Nonreplicating Persister Mycobacteria

Antimicrobial Agents and Chemotherapy
Mu-Lu WuThomas Dick

Abstract

We determined the microbicidal activities of antibacterials against nonreplicating Mycobacterium smegmatis grown in a starvation-based Loebel model for persistence. Whereas most drugs lost their activity, fluoroquinolones retained lethal potency. Dose-response characterizations showed a paradoxical more-drug-kills-less Eagle effect. Pretreatment of cultures with chloramphenicol blocked the lethal action of the gyrase inhibitors. These results suggest that fluoroquinolones at low concentrations trigger a protein synthesis-dependent cell death pathway and shut off this suicide pathway at elevated concentrations.

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Citations

Jan 26, 2020·FEMS Microbiology Reviews·Dan I AnderssonTone Tønjum
Jul 4, 2019·MBio·Diego A Vargas-BlancoScarlet S Shell
Feb 3, 2021·Critical Reviews in Microbiology·Susana Patrícia LopesMaria Olívia Pereira
Feb 26, 2021·Parasites & Vectors·Christina A BulmanJudy A Sakanari
Jul 18, 2018·International Journal of Antimicrobial Agents·Michael John AldapeDennis Leroy Stevens

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