Ear manipulations reveal a critical period for survival and dendritic development at the single-cell level in Mauthner neurons

Developmental Neurobiology
Karen L ElliottBernd Fritzsch

Abstract

Second-order sensory neurons are dependent on afferents from the sense organs during a critical period in development for their survival and differentiation. Past research has mostly focused on whole populations of neurons, hampering progress in understanding the mechanisms underlying these critical phases. To move toward a better understanding of the molecular and cellular basis of afferent-dependent neuronal development, we developed a new model to study the effects of ear removal on a single identifiable cell in the hindbrain of a frog, the Mauthner cell. Ear extirpation at various stages of Xenopus laevis development defines a critical period of progressively-reduced dependency of Mauthner cell survival/differentiation on the ear afferents. Furthermore, ear removal results in a progressively decreased reduction in the number of dendritic branches. Conversely, addition of an ear results in an increase in the number of dendritic branches. These results suggest that the duration of innervation and the number of inner ear afferents play a quantitative role in Mauthner cell survival/differentiation, including dendritic development.

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Citations

Dec 17, 2014·Cancer Treatment Reviews·Carmen CriscitielloGiuseppe Curigliano
Mar 24, 2017·Journal of the Association for Research in Otolaryngology : JARO·Richard RobertsMartha W Bagnall
Jun 28, 2017·Journal of the Experimental Analysis of Behavior·Kasra ZareiJames H J Buchholz
Oct 17, 2017·Developmental Neurobiology·Sanam ZareiKaren L Elliott
Jul 22, 2018·Developmental Neurobiology·Clayton GordyKaren L Elliott
Dec 20, 2018·Journal of the Association for Research in Otolaryngology : JARO·Sigmund J LilianKenna D Peusner
Jul 18, 2019·Scientific Reports·Jeremy S DuncanKaren L Elliott
Sep 16, 2018·Scientific Reports·Karen L Elliott, Bernd Fritzsch

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