Earlier onset of motor deficits in mice with double mutations in Dyt1 and Sgce.

Journal of Biochemistry
Fumiaki YokoiYuqing Li

Abstract

DYT1 early-onset generalized torsion dystonia is an inherited movement disorder caused by mutations in DYT1 coding for torsinA with ∼30% penetrance. Most of the DYT1 dystonia patients exhibit symptoms during childhood and adolescence. On the other hand, DYT1 mutation carriers without symptoms during these periods mostly do not exhibit symptoms later in their life. Little is known about what controls the timing of the onset, a critical issue for DYT1 mutation carriers. DYT11 myoclonus-dystonia is caused by mutations in SGCE coding for ε-sarcoglycan. Two dystonia patients from a single family with double mutations in DYT1 and SGCE exhibited more severe symptoms. A recent study suggested that torsinA contributes to the quality control of ε-sarcoglycan. Here, we derived mice carrying mutations in both Dyt1 and Sgce and found that these double mutant mice showed earlier onset of motor deficits in beam-walking test. A novel monoclonal antibody against mouse ε-sarcoglycan was developed by using Sgce knock-out mice to avoid the immune tolerance. Western blot analysis suggested that functional deficits of torsinA and ε-sarcoglycan may independently cause motor deficits. Examining additional mutations in other dystonia genes may be benef...Continue Reading

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Citations

Aug 24, 2013·PloS One·Fumiaki YokoiYuqing Li
Nov 2, 2013·Neurologic Clinics·Jeffrey L Waugh, Nutan Sharma
Jul 31, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Janneth OleasYuqing Li
May 28, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Fu-Bo ChengKathrin Grundmann
Jun 1, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Mark P DeAndradeYuqing Li
Jan 23, 2016·Molecular Neurobiology·Laila RachadSellama Nadifi
Apr 15, 2020·Journal of Neuroscience Methods·P ImbrianiA Pisani
Jan 1, 2020·Behavioural Brain Research·Fumiaki YokoiYuqing Li
Apr 23, 2021·Molecular Neurobiology·Ana Cazurro-GutiérrezBelén Pérez-Dueñas

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