Earlier seizure onset and longer epilepsy duration correlate with the degree of temporal hypometabolism in patients with mesial temporal lobe sclerosis

Epilepsy Research
Carlos Leiva-SalinasPatrice K Rehm

Abstract

To study the relationship of glucose metabolism and volume of the temporal lobes with age at epilepsy onset, epilepsy duration, and seizure frequency in patients with mesial temporal sclerosis (MTS). We evaluated the pre-surgical 18F-fluoro-deoxyglucose (FDG) positron emission tomography (PET) and magnetic resonance imaging (MRI) of 18 patients with epilepsy and MRI findings of MTS, who were seizure-free for at least 2-years after temporal lobectomy. We calculated the volume of the hippocampi and amygdalae on MRI. On PET we studied their mean standard uptake values (SUV), and relative metabolic activity as compared to normal subjects in terms of Z-scores. We compared the PET and MRI metrics in the bilateral structures using the Wilcoxon sign rank test. We studied the relationship between the imaging metrics and age of epilepsy onset, epilepsy duration, and seizure frequency via Spearman correlation analyses. Younger age at onset correlated with decreased hippocampal glucose metabolism (rs=0.64, p=0.008). Longer epilepsy duration correlated with decreased hippocampal glucose metabolism (rs=-0.55, p=0.024). There was no correlation between age at onset of epilepsy, epilepsy duration, or seizure frequency and volumetrics. Z-score ...Continue Reading

Citations

Jan 6, 2018·Current Opinion in Neurology·Tim J von Oertzen
Aug 30, 2020·Annals of Clinical and Translational Neurology·Jingjuan WangJie Lu
Jan 22, 2020·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Marius GasserCelina von Stülpnagel
Apr 21, 2021·Seizure : the Journal of the British Epilepsy Association·Hiroyuki TatekawaNoriko Salamon

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