Early- vs late-onset subcortical vascular cognitive impairment

Neurology
Young Kyoung JangHee Jin Kim

Abstract

To evaluate the differences between early-onset subcortical vascular cognitive impairment (EO-SVCI) and late-onset subcortical vascular cognitive impairment (LO-SVCI) with regard to pathologic burden, structural changes, and cognitive function. We prospectively recruited 142 patients from a single referral center. Patients were divided into EO-SVCI (n = 30, age at onset <65 years) and LO-SVCI (n = 112, age at onset ≥ 65 years) groups. All patients underwent neuropsychological tests, 3T brain MRI, and [(11)C] Pittsburgh compound B (PiB)-PET. We compared pathologic burden such as small vessel disease and amyloid burden; structural changes such as structural network, cortical thickness, and hippocampal volume; and cognitive function between EO-SVCI and LO-SVCI. EO-SVCI patients had more lacunes, while LO-SVCI patients had higher PiB standardized uptake value ratios. EO-SVCI patients exhibited more severe structural network disruptions in the frontal area, while LO-SVCI patients exhibited more severe cortical and hippocampal atrophy. Although disease severity did not differ between the 2 groups, frontal-executive dysfunction was more severe in EO-SVCI patients. EO-SVCI patients showed more vascular related factors, while LO-SVCI pa...Continue Reading

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Citations

Oct 7, 2017·Nature Reviews. Neurology·Nicholas R EvansElizabeth A Warburton
May 31, 2016·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·A A Kulesh, V V Shestakov
Oct 31, 2017·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J LeeH J Kim
Mar 23, 2018·Journal of Alzheimer's Disease : JAD·Anders WallinElisabeth Kapaki
Oct 31, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Sung Hoon KangSang Won Seo

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