PMID: 8580629Nov 1, 1995Paper

Early [18F]FDG positron emission tomography in infants with hypoxic-ischaemic encephalopathy shows hypermetabolism during the postasphyctic period

Acta Paediatrica
M BlennowO Flodmark

Abstract

Six full-term infants suffering from perinatal asphyxia and with moderate or severe hypoxic-ischaemic encephalopathy were investigated by positron emission tomography (PET). Regional cerebral metabolic rates of glucose (rCMRgl) were determined using [2-18F]2-fluoro-2-deoxy-D-glucose ([18F]FDG) PET scans at a median age of 2.5 days (range 2-5 days). Localized increases in rCMRgl were visually observed in five infants. In a subgroup of three infants, absolute values of rCMRgl in different brain regions were calculated. In all cases the results of the PET studies were in good agreement with those of the neuroradiological, neurophysiological and clinical investigations. Information indicating pathophysiological events could be extracted earlier with PET than with conventional morphological imaging techniques. We conclude that [18F]FDG-PET scans performed in critically ill, asphyxiated infants very soon after birth provide valuable information for the prediction about neurological outcome.

References

Sep 1, 1991·Neurochemical Research·M E Phelps
Nov 1, 1991·Pediatric Neurology·T S Rosenkrantz, E L Zalneraitis
Jun 1, 1990·Pediatric Research·C E WilliamsP D Gluckman
Dec 1, 1989·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K ShiraishiR P Simon
Oct 1, 1988·Critical Care Medicine·B K Siesjö
Oct 1, 1987·Annals of Neurology·H T ChuganiJ C Mazziotta
Jun 1, 1985·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A GjeddeG Pawlik
Jun 1, 1985·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M ReivichA Anand
Apr 1, 1983·Developmental Medicine and Child Neurology·L W DoyleJ C Sinclair
May 1, 1994·European Journal of Nuclear Medicine·W D Heiss, K Herholz

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Citations

Jan 5, 2002·Mental Retardation and Developmental Disabilities Research Reviews·M V Johnston
Jan 25, 2014·Lancet Neurology·Henrik HagbergClaire Thornton
Feb 20, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·E GillandH Hagberg
Jun 17, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·W J PowersT O Videen
Sep 4, 1998·Pediatric Research·J D HanrahanD Azzopardi
Jun 1, 2001·Pediatric Research·M V JohnstonW Nakajima
Feb 3, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Charlotte de LangeBerit H Munkeby
Jul 29, 2009·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Masao WatanabeTatsuo Yamamoto
Apr 6, 2016·Neural Plasticity·Eridan Rocha-Ferreira, Mariya Hristova
May 9, 2007·General Hospital Psychiatry·Numan KonukBora Bostanci
Nov 3, 2016·Pediatric Research·Floris Groenendaal, Linda S de Vries
Jun 14, 2002·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Michael V JohnstonHenrik Hagberg
Jan 31, 2006·Free Radical Biology & Medicine·Klas Blomgren, Henrik Hagberg
May 19, 2007·Pediatric Neurology·Carlos E A BatistaSeetha Shankaran
Mar 14, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·E GillandH Hagberg
Aug 17, 2018·Journal of Child Neurology·Harry T Chugani
Feb 7, 2015·Stroke; a Journal of Cerebral Circulation·Fabian ArnbergStaffan Holmin
Oct 4, 2005·Brain Pathology·Michael V Johnston
Jul 1, 1997·Acta Paediatrica. Supplement·H HagbergM Puka-Sundvall
Dec 18, 2001·Journal of Neuroscience Research·K Thorngren-JerneckK Marsal
Jul 23, 2018·Journal of Molecular Neuroscience : MN·Lorelei Donovan TuckerQuanguang Zhang
Feb 23, 2000·Experimental Neurology·W MosgoellerB Lubec
Aug 26, 1998·Annals of Neurology·M V Johnston

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