Early Acquisition of Pneumocystis jirovecii Colonization and Potential Association With Respiratory Distress Syndrome in Preterm Newborn Infants

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Pilar RojasAntonio Pavón

Abstract

Pneumocystis pneumonia is a well-recognized lung disease of premature and malnourished babies. Even though serologic studies have shown that children are exposed to Pneumocystis jirovecii early in life, the epidemiology of human P. jirovecii infection and the host-microorganism relationship in infancy remain poorly understood. The aim of the present study was to investigate the prevalence of P. jirovecii colonization in preterm infants and its possible association with medical complications. A prospective observational study of preterm infants (birth weight <1500 g and/or gestational age <32 weeks) was carried out. Identification of P. jirovecii colonization was performed by means of molecular techniques in nasal aspirated samples at birth. A total of 128 preterm infants were included during the study period. Pneumocystis DNA was identified in 25.7% (95% confidence interval [CI], 17.8%-33.7%) of newborns studied. A significant increase of respiratory distress syndrome in colonized group, even after adjusting for confounding factors (odds ratio, 2.7 [95% CI, 1.0-7.5]; P = .04), was observed. No differences were observed in other medical conditions between the 2 groups. Pneumocystis jirovecii colonization is frequent in preterm b...Continue Reading

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Citations

Feb 21, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Gilles NevezSolène Le Gal
Feb 21, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Pilar RojasAntonio Pavón
Sep 16, 2017·European Journal of Pediatrics·Cristian VeraZulma Vanessa Rueda
Oct 18, 2018·Journal of Medical Microbiology·Theodore J KottomAndrew H Limper
Sep 26, 2019·Expert Review of Anti-infective Therapy·Catia CillónizJosé M Miro
Dec 20, 2018·Medical Mycology·Patrizia DanesiRichard Malik
Nov 6, 2020·Microorganisms·Esther Rubio-PortilloMaría Francisca Colom
Aug 7, 2021·Journal of Fungi·Estelle MenuCoralie L'Ollivier
Apr 16, 2021·The Journal of Infectious Diseases·Magdalena SzydłowiczMarta Kicia
Jul 22, 2021·The Journal of Infectious Diseases·Theodore J KottomAndrew H Limper

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