Early Activation of Astrocytes does not Affect Amyloid Plaque Load in an Animal Model of Alzheimer's Disease

Neuroscience Bulletin
Dongpi WangBinggui Sun

Abstract

Astrocytes are closely associated with Alzheimer's disease (AD). However, their precise roles in AD pathogenesis remain controversial. One of the reasons behind the different results reported by different groups might be that astrocytes were targeted at different stages of disease progression. In this study, by crossing hAPP (human amyloid precursor protein)-J20 mice with a line of GFAP-TK mice, we found that astrocytes were activated specifically at an early stage of AD before the occurrence of amyloid plaques, while microglia were not affected by this crossing. Activation of astrocytes at the age of 3-5 months did not affect the proteolytic processing of hAPP and amyloid plaque loads in the brains of hAPP-J20 mice. Our data suggest that early activation of astrocytes does not affect the deposition of amyloid β in an animal model of AD.

References

May 22, 2002·Neurochemistry International·I SuárezB Fernández
Mar 4, 2003·Nature Medicine·Tony Wyss-CorayJens Husemann
Jul 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jorge J PalopLennart Mucke
Oct 21, 2004·Nature Neuroscience·A Denise R GarciaMichael V Sofroniew
Oct 27, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ke-Jie YinJin-Moo Lee
May 16, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Vanessa HouadesChristian Giaume
Dec 15, 2010·Current Alzheimer Research·Chuanyu LiAlbert Cheung Hoi Yu
Mar 20, 2012·Cell·Yadong Huang, Lennart Mucke
Oct 6, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Andrew W KraftJin-Moo Lee
Nov 16, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jennifer L FurmanChristopher M Norris
Jun 19, 2013·Proceedings of the National Academy of Sciences of the United States of America·Maria TalantovaStuart A Lipton
Feb 25, 2014·Neuron·Takahisa KanekiyoGuojun Bu
Mar 4, 2014·Nature Neuroscience·Ulrike PannaschNathalie Rouach
Mar 21, 2015·Lancet Neurology·Michael T HenekaMarkus P Kummer
Apr 22, 2015·Nature Reviews. Neuroscience·Michael V Sofroniew
May 27, 2015·Nature Neuroscience·Erik S Musiek, David M Holtzman
Jun 26, 2015·Nature Neuroscience·Baljit S Khakh, Michael V Sofroniew
Nov 19, 2015·Development·J Bradley Zuchero, Ben A Barres
Dec 4, 2015·Nature Reviews. Neuroscience·Yipeng Wang, Eckhard Mandelkow
Dec 17, 2015·Acta Neuropathologica·Milos PeknyAlexei Verkhratsky
Jan 23, 2016·Progress in Neurobiology·Lana M OsbornElly M Hol

❮ Previous
Next ❯

Citations

Jan 9, 2019·EMBO Molecular Medicine·Nicole ReichenbachGabor C Petzold
Oct 31, 2019·Neuroscience Bulletin·Yurong ZhangHongliu Sun
Jul 19, 2019·Reviews in the Neurosciences·Jian-Jiao ChenShao Li
Sep 11, 2019·Cell Death & Disease·Xiu SunZhida Su
Jan 28, 2021·Neurochemistry International·Sukanya Sarkar, Subhas C Biswas
Dec 22, 2020·Frontiers in Cellular Neuroscience·Han QinKuan Zhang

❮ Previous
Next ❯

Software Mentioned

Graphpad Prism
Quantity One

Related Concepts

Related Feeds

Astrocytes & Amyloid

Astrocytes are thought to play a role in amyloid production and have been implicated in neurodegenerative diseases such as Alzheimer’s disease. Here is the latest research on the relationship between astrocytes and amyloid.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Alzheimer's Disease: Microglia

Microglia are a type of glial cell found throughout the brain and spinal cord. Microglia have been found to be associated with Alzheimer's disease development and progression. Here are the latest discoveries pertaining to Alzheimer's disease and microglia.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.