Early activation of deleterious molecular pathways in the kidney in experimental heart failure with atrial remodeling

Physiological Reports
Tomoko IchikiJohn C Burnett

Abstract

Heart failure (HF) is a major health problem with worsening outcomes when renal impairment is present. Therapeutics for early phase HF may be effective for cardiorenal protection, however the detailed characteristics of the kidney in early-stage HF (ES-HF), and therefore treatment for potential renal protection, are poorly defined. We sought to determine the gene and protein expression profiles of specific maladaptive pathways of ES-HF in the kidney and heart. Experimental canine ES-HF, characterized by de-novo HF with atrial remodeling but not ventricular fibrosis, was induced by right ventricular pacing for 10 days. Kidney cortex (KC), medulla (KM), left ventricle (LV), and left atrial (LA) tissues from ES-HF versus normal canines (n = 4 of each) were analyzed using RT-PCR microarrays and protein assays to assess genes and proteins related to inflammation, renal injury, apoptosis, and fibrosis. ES-HF was characterized by increased circulating natriuretic peptides and components of the renin-angiotensin-aldosterone system and decreased sodium and water excretion with mild renal injury and up-regulation of CNP and renin genes in the kidney. Compared to normals, widespread genes, especially genes of the inflammatory pathways, we...Continue Reading

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Citations

Mar 7, 2019·American Journal of Physiology. Renal Physiology·Shan Liu
Jul 3, 2020·Circulation. Heart Failure·Vijay Ramakrishnan, John C Burnett
Feb 9, 2019·BMC Cardiovascular Disorders·Uma ChandrasekaranHaroon Faraz

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Methods Mentioned

BETA
urine collection
ELISA
PCR

Software Mentioned

KS 400

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