Early adjuvant radiotherapy in the treatment of atypical meningioma

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Michael D JenkinsonMohsen Javadpour

Abstract

Atypical meningiomas have a greater propensity to recur than benign meningiomas and the benefits of early adjuvant radiotherapy are unclear. Existing studies report conflicting results. This retrospective cohort study evaluated the role of early adjuvant radiotherapy following surgical resection of atypical meningioma. A triple center case-note review of adults with newly-diagnosed atypical meningiomas between 2001 and 2010 was performed. Pathology diagnosis was made according to the World Health Organization classification in use at the time of surgery. Patients with multiple meningiomas, neurofibromatosis type 2 and radiation-induced meningiomas were excluded. Extent of resection was defined as gross total resection (GTR; Simpson Grade I-III) or subtotal resection (STR; Simpson Grade IV-V). Survival analysis was performed using the Kaplan-Meier method. One hundred thirty-three patients were identified with a median age of 62years (range 22-86years) and median follow-up of 57.4months (range 0.1-152.2months). Tumors were mostly located in the convexity (50.4%) or falcine/parasagittal regions (27.1%). GTR (achieved in 85%) was associated with longer progression free survival (PFS) (5year PFS 81.2% versus 40.08%, log-rank=11.117,...Continue Reading

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Apr 30, 2017·World Neurosurgery·Christopher S GraffeoAditya Raghunathan
Feb 27, 2018·Journal of Neuro-oncology·William C ChenSteve E Braunstein
May 11, 2017·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Majed AlghamdiGerald Lim
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Apr 13, 2021·Journal of Neurological Surgery. Part A, Central European Neurosurgery·Meike UnteroberdörsterDaniela Pierscianek
Jun 5, 2018·Practical Radiation Oncology·Sidharth PantTejpal Gupta

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