Early administration of intravenous magnesium inhibits arterial thrombus formation

Arteriosclerosis, Thrombosis, and Vascular Biology
H B RavnS E Husted

Abstract

An antiplatelet effect of magnesium has been demonstrated in vitro and ex vivo, and this effect may be advantageous in patients with acute myocardial infarction to inhibit reocclusion after coronary angioplasty or thrombolysis. We investigated the antithrombotic in vivo effect of intravenous magnesium in a placebo-controlled, blinded study in 46 male Wistar rats. Thrombus formation was induced by standardized arteriotomy of the femoral artery and partial inversion of the vessel wall to produce a thrombogenic area. The vessel was transilluminated and visualized dynamically by in vivo microscopy. Thrombus area was measured every minute for 30 minutes after removal of the vessel clamp by image analysis techniques, and the number of visible emboli was registered. Animals were randomized into three groups: groups 1 and 2 received saline (control group, n = 15) or MgSO4 (Mg-early group, n = 15), respectively, during the entire infusion period. In group 3 intravenous saline was given during preparation of the arteriotomy followed by infusion of MgSO4 (Mg-late group, n = 16) from 10 minutes after removal of the vessel clamp. Thrombus area was significantly reduced by 75% in the Mg-early group (P < .005) but not in the Mg-late group com...Continue Reading

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Citations

Oct 11, 2002·Microsurgery·Dorthe M AndresenVibeke E Hjortdal
Jan 23, 2003·Molecular Aspects of Medicine·Pietro Delva
Nov 21, 2002·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·J FuglsangH B Ravn
Jan 20, 2004·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Michael Shechter
Sep 6, 2012·Journal of Thrombosis and Haemostasis : JTH·D M RøpckeS D Kristensen
Jul 19, 2001·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·H B RavnA T Kristensen
May 26, 2004·Biochimica Et Biophysica Acta·Jeanette A M MaierAndrzej Mazur
Jul 22, 2010·Annales de chirurgie plastique et esthétique·L-A DumontI Garrido-Stowhas

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