Early Airway Pathological Changes in Children: New Insights into the Natural History of Wheezing

Journal of Clinical Medicine
Matteo BonatoSimonetta Baraldo

Abstract

Asthma is a heterogeneous condition characterized by reversible airflow limitation, with different phenotypes and clinical expressions. Although it is known that asthma is influenced by age, gender, genetic background, and environmental exposure, the natural history of the disease is still incompletely understood. Our current knowledge of the factors determining the evolution from wheezing in early childhood to persistent asthma later in life originates mainly from epidemiological studies. The underlying pathophysiological mechanisms are still poorly understood. The aim of this review is to converge epidemiological and pathological evidence early in the natural history of asthma to gain insight into the mechanisms of disease and their clinical expression.

References

Nov 1, 1978·Histopathology·E CutzD M Cooper
May 13, 1995·BMJ : British Medical Journal·S L JohnstonD A Tyrrell
Jan 19, 1995·The New England Journal of Medicine·F D MartinezW J Morgan
May 12, 2000·American Journal of Respiratory and Critical Care Medicine·N SigursB Kjellman
Apr 24, 2001·Archives of Disease in Childhood·D PayneA Bush
Dec 6, 2001·American Journal of Respiratory and Critical Care Medicine·P K Jeffery
Dec 12, 2001·American Journal of Respiratory and Critical Care Medicine·L M van den ToornJ B Prins
Mar 30, 2002·Thorax·N G PapadopoulosS L Johnston
Oct 24, 2002·The European Respiratory Journal. Supplement·M Saetta, G Turato
Dec 28, 2002·American Journal of Respiratory and Critical Care Medicine·Donald N R PaynePeter K Jeffery
Apr 3, 2003·The Pediatric Infectious Disease Journal·Fernando D Martinez
Jul 11, 2003·Chest·Henry A JenkinsJoseph D Spahn
Aug 2, 2003·American Journal of Respiratory and Critical Care Medicine·Angelo BarbatoMarina Saetta
Oct 10, 2003·The New England Journal of Medicine·Malcolm R SearsRichie Poulton
Oct 30, 2003·The European Respiratory Journal. Supplement·S T HolgateP Howarth
Feb 7, 2004·American Journal of Respiratory and Critical Care Medicine·Stephen W TurnerPeter N Le Souëf
May 12, 2004·Paediatric Respiratory Reviews·Renato T Stein, Fernando D Martinez
Oct 27, 2004·American Journal of Respiratory and Critical Care Medicine·Lesley A LoweUNKNOWN NAC Manchester Asthma and Allergy Study Group
Dec 4, 2004·The Journal of Allergy and Clinical Immunology·Theresa W GuilbertFernando D Martinez
Jan 20, 2005·American Journal of Respiratory and Critical Care Medicine·Sejal SaglaniPeter K Jeffery
Aug 23, 2005·Proceedings of the American Thoracic Society·Stephen T HolgateDonna E Davies
Sep 15, 2005·The Journal of Allergy and Clinical Immunology·Robert F LemanskeJames E Gern
Aug 15, 2006·Nature Medicine·Marco ContoliSebastian L Johnston
Aug 19, 2006·American Journal of Respiratory and Critical Care Medicine·Angelo BarbatoMarina Saetta
Mar 14, 2007·The Journal of Allergy and Clinical Immunology·Merci M H KuselPeter D Sly
Aug 11, 2007·The Journal of Allergy and Clinical Immunology·Debra A SternFernando D Martinez
Aug 19, 2007·American Journal of Respiratory and Critical Care Medicine·Sejal SaglaniPeter K Jeffery
Jan 26, 2008·American Journal of Respiratory and Critical Care Medicine·Nicolas RegameyJane C Davies
Feb 9, 2008·COPD·Andrew Bush
Apr 16, 2008·Respirology : Official Journal of the Asian Pacific Society of Respirology·William K MidodziAmbikaipakan Senthilselvan
May 31, 2008·American Journal of Respiratory and Critical Care Medicine·Graziella TuratoMarina Saetta
Jun 21, 2008·American Journal of Respiratory and Critical Care Medicine·Daniel J JacksonRobert F Lemanske
Dec 17, 2008·Pediatric Pulmonology·Nicolas RegameyJane C Davies
Aug 12, 2009·The Journal of Allergy and Clinical Immunology·Daan CaudriJohan C de Jongste
Sep 4, 2010·American Journal of Respiratory and Critical Care Medicine·Martine BroekemaDirkje S Postma
Sep 24, 2010·The New England Journal of Medicine·Miriam F MoffattUNKNOWN GABRIEL Consortium
Apr 21, 2011·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Chunju ZhouShunying Zhao
Jan 12, 2012·European Journal of Pediatrics·Lucie Kappelle, Paul L P Brand

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Citations

Mar 7, 2021·The Journal of Allergy and Clinical Immunology·Lei FangMichael Roth
Apr 17, 2021·PloS One·Yasuaki SaijoUNKNOWN Japan Environment and Children’s Study (JECS) Group
May 15, 2021·Frontiers in Physiology·Marta SchiliroChristina M Pabelick
Jul 14, 2021·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Ramiro González VeraJose A Castro-Rodriguez

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Methods Mentioned

BETA
biopsy
bronchoalveolar lavage
biopsies

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