PMID: 3758544Aug 1, 1986Paper

Early alveolar clearance of particles in rabbits undergoing acute and subchronic exposure to ozone

Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology
K E DriscollR B Schlesinger

Abstract

The concentration-response relationship for changes in early alveolar clearance resulting from O3 inhalation were investigated. Groups of five rabbits were exposed to 0.0, 0.1, 0.6, or 1.2 ppm O3, 2 hr/day X 1 day; or to 0.0, 0.1, or 0.6 ppm O3, 2 hr/day X 13 days. Following the initial O3 exposure all rabbits inhaled an aerosol of 85Sr-tagged, 3.0-micron, polystyrene latex particles and particle retention was determined daily for the following 14 days. Single exposures to O3 produced a concentration related trend from accelerated clearance at 0.1 ppm to a transient impairment of clearance at 1.2 ppm. Subchronic exposure resulted in a significant acceleration of particle clearance at both 0.1 and 0.6 ppm, with the effect more pronounced at the higher level. These results demonstrate that single or repeated exposure of rabbits to 0.1 ppm O3, a level below the current National Ambient Air Quality Standard, produces alterations in early alveolar clearance. The effects observed at higher levels of O3 appeared to depend on both the concentration and exposure regime; acute exposures produced a concentration related trend toward an initial retardation of clearance, which was followed by an acceleration in particle removal, while repea...Continue Reading

Citations

Jan 1, 1990·Free Radical Biology & Medicine·M G Mustafa
Dec 18, 1996·Toxicology·M D CohenR B Schlesinger
Feb 18, 2003·Journal of Toxicology and Environmental Health. Part a·Mitchell D CohenRichard B Schlesinger
Jan 1, 1987·Journal of Toxicology and Environmental Health·R B Schlesinger, K E Driscoll
Jan 1, 1987·Journal of Toxicology and Environmental Health·R B Schlesinger
Oct 1, 1989·The American Review of Respiratory Disease·K E PinkertonJ D Crapo
May 1, 1989·Environmental Health Perspectives·R B Schlesinger
Nov 18, 2008·Mutation Research·Wei Yang, Stanley T Omaye
Oct 17, 1998·Toxicology and Applied Pharmacology·M D CohenR B Schlesinger
Feb 27, 2001·Toxicology and Applied Pharmacology·M D CohenR B Schlesinger
Oct 23, 1997·British Journal of Obstetrics and Gynaecology·M Wingfield, P Boylan
Jan 1, 1994·British Journal of Obstetrics and Gynaecology·K S Oláh, J P Neilson
Jan 1, 1988·British Journal of Obstetrics and Gynaecology
Jan 1, 1990·Critical Reviews in Toxicology·R B Schlesinger
Apr 13, 1991·BMJ : British Medical Journal·M J Turner
Apr 13, 1991·BMJ : British Medical Journal·R Kulkarni, W P Bradford
Apr 13, 1991·BMJ : British Medical Journal
Sep 15, 1991·Toxicology and Applied Pharmacology·S BeckerH S Koren

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