PMID: 8587866Oct 1, 1995Paper

Early amniocentesis and fetal nuchal translucency in women requesting karyotyping for advanced maternal age

Prenatal Diagnosis
D R Salvesen, O Goble

Abstract

Fetal nuchal translucency was measured at 11-14 weeks' gestation in 97 pregnancies referred for early amniocentesis for advanced maternal age. The nuchal translucency was abnormal in 11 fetuses and the fetal karyotype was abnormal in five of these 11 cases. The karyotype was normal in 86 cases with normal nuchal translucency. The culture failure and miscarriage rates associated with early amniocentesis were 3.3 per cent and 2.2 per cent respectively. Amniotic fluid leakage occurred in 6 per cent of cases. In women requesting fetal karyotyping for advanced maternal age without additional biochemical screening, fetal nuchal translucency should be measured at 11-14 weeks. If the nuchal thickness is > or = 3 mm, a first-trimester diagnostic procedure is indicated; however, if it is < 3 mm, amniocentesis should be delayed until 16 weeks' gestation.

References

Jan 1, 1991·Fetal Diagnosis and Therapy·D ByrneK Nicolaides
Nov 29, 1986·Lancet·A M Smith
Sep 1, 1994·British Journal of Obstetrics and Gynaecology·K H NicolaidesR J Snijders

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Citations

Aug 8, 2001·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·A P SoukaK H Nicolaides
Jul 13, 2001·Journal of Perinatal Medicine·C Sen
Jul 20, 2010·Clinics in Laboratory Medicine·Laura Goetzl
Nov 9, 2000·Seminars in Perinatology·P C Devine, L L Simpson
Apr 23, 2005·American Journal of Obstetrics and Gynecology·Athena P SoukaKypros H Nicolaides
Aug 14, 2001·Clinics in Perinatology·R Snijders
Feb 17, 2007·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Jiri Sonek

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