Early and dynamic alterations of Th2/Th1 in previously immunocompetent patients with community-acquired severe sepsis: a prospective observational study

Journal of Translational Medicine
Ming XueHaibo Qiu

Abstract

T helper (Th) cells regulate sepsis processes, including primary pathogen clear and secondary pathogen defence. The objectives of this study were to determine the early and dynamic alterations of Th1 and Th2 populations to community-acquired severe sepsis upon onset among previously immunocompetent patients and whether it was related to clinical outcomes. This prospective observational cohort study was conducted at a general intensive care unit (ICU) of a tertiary teaching hospital in China. Immunocompetent patients with community-acquired severe sepsis within 24 h upon onset were included as septic group. Healthy volunteers and critically ill patients without severe sepsis were recruited as controls. Whole blood was collected on D0, 3rd day (D3) and 7th day (D7) for septic group and once upon enrollment for controls. Th1 and Th2 populations were measured by flow cytometry and assessed for associations with 28-day mortality using cox proportional hazard models. Associations of dynamic alterations of Th cell subpopulations with clinical outcomes were investigated. This study demonstrated that community-acquired severe sepsis patients (n = 71) had increased Th2/Th1 and Th2 populations, compared to healthy controls (n = 7) and cri...Continue Reading

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Citations

Mar 11, 2021·Journal of Inflammation Research·Zhenhua LiNian Chen
Mar 20, 2021·Journal of Inflammation Research·Xiaoliang ZengJianfeng Zhang
Aug 26, 2021·Journal of Veterinary Emergency and Critical Care·Sophie E SageMary Rose Paradis
Oct 19, 2021·Frontiers in Immunology·Andrew SnyderJennifer A Muszynski

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Methods Mentioned

BETA
flow cytometry
ELISA

Clinical Trials Mentioned

NCT02883218

Software Mentioned

SPSS
Power Analysis and Sample Size ( PASS )
GraphPad PRISM
PASS

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