Early and late morbidity of local excision after chemoradiotherapy for rectal cancer.

BJS Open
B TesteE Rullier

Abstract

Local excision (LE) after chemoradiotherapy is a new option in low rectal cancer, but morbidity has never been compared prospectively with total mesorectal excision (TME). Early and late morbidity were compared in patients treated either by LE or TME after neoadjuvant chemoradiotherapy for rectal cancer. This was a post-hoc analysis from a randomized trial. Patients with clinical T2/T3 low rectal cancer with good response to the chemoradiotherapy and having either LE, LE with eventual completion TME, or TME were considered. Early (1 month) and late (2 years) morbidities were compared between the three groups. There were no deaths following surgery in any of the three groups. Early surgical morbidity (20 per cent LE versus 36 per cent TME versus 43 per cent completion TME, P = 0.025) and late surgical morbidity (4 per cent versus 33 per cent versus 57 per cent, P < 0.001) were significantly lower in the LE group than in the TME or the completion TME group. of LE, was associated with the lowest rate of early (10 versus 18 versus 21 per cent, P = 0.217) and late medical morbidities (0 versus 7 versus 7 per cent, P = 0.154), although this did not represent a significant difference between the groups. The severity of overall morbidi...Continue Reading

References

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Feb 12, 2013·The Lancet Oncology·Martijn Hgm van der PasUNKNOWN COlorectal cancer Laparoscopic or Open Resection II (COLOR II) Study Group
Nov 10, 2013·Diseases of the Colon and Rectum·Salvatore PucciarelliClaudio Coco
Aug 12, 2016·Journal of the National Cancer Institute·Milou H MartensGeerard L Beets
Sep 8, 2016·Diseases of the Colon and Rectum·Sally HallamMichael G Thomas

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