Early and late onset fetal microphthalmia

American Journal of Obstetrics and Gynecology
Shraga BlazerMoshe Bronshtein

Abstract

The purpose of this study was to present sonographic and pathologic findings in early and late onset fetal microphthalmia. Fetal sonography was prospectively performed in 30,989 consecutive pregnancies at 14 to 24 weeks' gestation. In addition, we retrospectively reevaluated US recordings of 4 fetuses from other hospitals, in which normal eyes were observed in early and midgestation and microphthalmia was diagnosed only in the third trimester of pregnancy or after birth. Microphthalmia was detected in 13 fetuses in the prospective group. Twelve of 13 had additional structural and chromosomal anomalies. Termination of pregnancy was performed in 12 cases. In the retrospective group of late onset microphthalmia we confirmed the normal eye measurements performed in the early and midpregnancy. Severe vision impairment or blindness was noted in 3 of these children, while the fourth pregnancy was terminated. Normal measurements of the fetal eyes in early and midpregnancy do not exclude the possibility of subsequent development of microphthalmia.

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Citations

Nov 28, 2007·Orphanet Journal of Rare Diseases·Amit S Verma, David R Fitzpatrick
Jun 23, 2009·AJNR. American Journal of Neuroradiology·L B PaquetteA Panigrahy
Jun 26, 2013·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Karine Duarte BojikianAntonio Fernandes Moron
May 6, 2015·Journal of Pediatric Ophthalmology and Strabismus·Suhail A DarArun D Singh
Feb 18, 2009·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·F StriginiR Battini
Oct 22, 2008·Journal of Clinical Ultrasound : JCU·Kanchapan Sukonpan, Vorapong Phupong
Sep 10, 2010·Prenatal Diagnosis·Xiao Bing LiDaniela Prayer
Jan 21, 2015·Prenatal Diagnosis·Clemente Velasco-AnnisSimon K Warfield
Jan 18, 2017·European Journal of Human Genetics : EJHG·Rose RichardsonMariya Moosajee
Feb 12, 2008·Prenatal Diagnosis·Andrea RighiniGaetano Bulfamante
Jan 4, 2020·European Journal of Human Genetics : EJHG·Jonathan EintrachtMariya Moosajee

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