Early and late preeclampsia are characterized by high cardiac output, but in the presence of fetal growth restriction, cardiac output is low: insights from a prospective study

American Journal of Obstetrics and Gynecology
Jasmine TayChristoph C Lees

Abstract

Preeclampsia and fetal growth restriction are considered to be placentally mediated disorders. The clinical manifestations are widely held to relate to gestation age at onset with early- and late-onset preeclampsia considered to be phenotypically distinct. Recent studies have reported conflicting findings in relation to cardiovascular function, and in particular cardiac output, in preeclampsia and fetal growth restriction. We conducted this study to examine the possible relation between cardiac output and peripheral vascular resistance in preeclampsia and fetal growth restriction. We investigated maternal cardiovascular function in relation to clinical subtype in 45 pathological pregnancies (14 preeclampsia only, 16 fetal growth restriction only, 15 preeclampsia and fetal growth restriction) and compared these with 107 healthy person observations. Cardiac output was the primary outcome measure and was assessed using an inert gas-rebreathing method (Innocor), from which peripheral vascular resistance was derived; arterial function was assessed by Vicorder, a cuff-based oscillometric device. Cardiovascular parameters were normalized for gestational age in relation to healthy pregnancies using Z scores, thus allowing for compariso...Continue Reading

Citations

Jun 8, 2018·Journal of Thrombosis and Haemostasis : JTH·J M WatJ C Kingdom
Jan 24, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Wilfried GyselaersLiesbeth Bruckers
Jun 25, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Tamara StampalijaEnrico Ferrazzi
Feb 10, 2019·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·R C BijlUNKNOWN International Working Group on Maternal Hemodynamics
Jul 26, 2019·The Journal of Physiology·Wilfried Gyselaers, Basky Thilaganathan
Nov 22, 2019·The Journal of Obstetrics and Gynaecology Research·Xiuhua HanLili Sun
Aug 23, 2019·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·A KhalilZ Alfirevic
Mar 7, 2020·BJOG : an International Journal of Obstetrics and Gynaecology·Hua Zen LingNikos A Kametas
Jul 19, 2020·Journal of Clinical Medicine·Wilfried Gyselaers
Sep 11, 2020·Journal of Clinical Medicine·Giulia MasiniChristoph C Lees
Dec 15, 2018·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·H PerryA Khalil
May 24, 2020·International Journal of Molecular Sciences·Diana Medina-BastidasGuadalupe Estrada-Gutierrez
Apr 26, 2019·Frontiers in Physiology·Grigorios KalapotharakosStefan R Hansson
Nov 7, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Qianlan GuoHongmei Li
Apr 11, 2020·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·S Yagel, S Verlohren
Oct 22, 2020·Acta Obstetricia Et Gynecologica Scandinavica·Elvira Di PasquoTiziana Frusca
Dec 29, 2020·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Katie J StephensChristoph C Lees
Jul 28, 2020·American Journal of Obstetrics and Gynecology·Piotr DobrowolskiPiotr Hoffman
Oct 17, 2020·Pregnancy Hypertension·Laura SarnoMaurizio Guida
Feb 14, 2021·Clinical Chemistry and Laboratory Medicine : CCLM·Paula Lafuente-GanuzaFrancisco V Alvarez
Dec 22, 2020·American Journal of Obstetrics and Gynecology·Hua Zen LingNikos A Kametas
Sep 24, 2018·American Journal of Obstetrics and Gynecology·Jasmine TayChristoph C Lees
Apr 3, 2021·American Journal of Physiology. Heart and Circulatory Physiology·María M PereiraDaniel Bia
May 6, 2021·Minerva Obstetrics and Gynecology·Francesco MarasciuloFederico Prefumo
Feb 17, 2021·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·H Z LingN A Kametas
Apr 23, 2021·Developmental Medicine and Child Neurology·Kuan-Ru ChenPao-Lin Kuo
Jun 22, 2019·American Journal of Obstetrics and Gynecology·Julio MateusKatherine L Grantz
Sep 7, 2021·American Journal of Obstetrics and Gynecology·Deesha PatelMakrina D Savvidou
Sep 18, 2021·American Journal of Obstetrics and Gynecology·Giulia MasiniChristoph C Lees
Mar 7, 2020·American Journal of Obstetrics and Gynecology·Barbara VasapolloHerbert Valensise

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