Early and six-month outcome in patients with angina pectoris early after acute myocardial infarction (the GISSI-3 APPI [angina precoce post-infarto] study)

The American Journal of Cardiology
GISSI-3 APPI Study Group

Abstract

There is conflicting evidence whether or not early postinfarction angina implies an unfavorable prognosis. This prospective study assessed the significance and natural history of early angina in a broad population of patients conservatively managed after acute myocardial infarction (AMI) and enrolled in the third Gruppo Italiano per lo Studio della Sopravvivenza nel Infarto Miocardico (GISSI-3) trial. Out of 2,363 consecutive patients (age 63 +/- 11; first AMI in 86%; thrombolysis in 74%) admitted in 31 centers lacking on-site revascularization facilities, early angina associated with transient electrocardiographic (ECG) changes was documented in 332 (14%). At multivariate analysis, preinfarction angina, age > or = 70 years, female gender, and history of infarct were significant predictors of early angina. Though the in-hospital course was free from major cardiac events in 78% of patients after the first anginal episode, reinfarction was more common after early angina (7% vs 2% in patients without, RR 3.1, 95% confidence interval [CI] 1.9 to 5.6; p <0.001), and death occurred in 7% of patients with early angina (vs 5% of patients without, RR 1.4, CI 0.9 to 2.4, p = NS). No demographic or clinical characteristics identified pati...Continue Reading

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Citations

May 26, 2009·European Heart Journal·Andrew J HogarthJohn P Greenwood
Dec 7, 2010·Progress in Cardiovascular Diseases·Borejda Xhyheri, Raffaele Bugiardini
May 19, 2005·Revista española de cardiología·Eulogio García
Jan 6, 2006·Srpski arhiv za celokupno lekarstvo·Predrag ErcegMiodrag Rajić
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Sep 27, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Predrag ErcegDragoslav P Milosevic

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