Early and Sustained Changes in Bone Metabolism After Severe Burn Injury

The Journal of Clinical Endocrinology and Metabolism
Gabriela Katharina MuschitzChristian Muschitz

Abstract

Severe burn injury causes a massive stress response, consecutively heightened serum levels of acute phase proteins, cortisol, and catecholamines with accompanying disturbance in calcium metabolism. Evaluation of early and prolonged changes of serum bone turnover markers (BTMs) and regulators of bone metabolism. Longitudinal observational design. University clinic. A total of 32 male patients with a median age of 40.5 years and a median burned total body surface area of 40% (83% patients with full thickness burn injury). None. Comparison of changes of BTM/regulators of bone metabolism in the early (d 2–7) and prolonged (d 7–56) phases after trauma. All investigated BTM/regulators significantly changed. During the early phase, pronounced increases were observed for serum type 1 collagen cross-linked C-telopeptide, intact N-terminal propeptide of type I procollagen, sclerostin, Dickkopf-1, bone-specific alkaline phosphatase, fibroblast growth factor 23, and intact parathyroid hormone levels, whereas 25-hydroxyvitamin D, albumin, serum, and ionized calcium levels decreased. Changes of osteoprotegerin, osteocalcin, and phosphate were less pronounced but remained significant. In the prolonged phase, changes of intact N-terminal prope...Continue Reading

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Citations

Sep 1, 2016·Burns : Journal of the International Society for Burn Injuries·Anne-Françoise RousseauEtienne Cavalier
Aug 27, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·V SchwetzK Amrein
Jul 2, 2017·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Gabriela Katharina MuschitzChristian Muschitz
Aug 15, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Jakob E SchandaChristian Muschitz
Dec 6, 2020·Bone·Salvador Israel Macías-HernándezJuan Daniel Morones-Alba
Jan 26, 2021·Bone Reports·Stephanie N Moore-LotridgeJonathan G Schoenecker
Jun 12, 2020·Burns : Journal of the International Society for Burn Injuries·Joseph BourgiGeorges Ghanimé

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