Early and sustained virological response in non-responders with chronic hepatitis C: a randomized open-label study of pegylated interferon-alpha-2a versus pegylated interferon-alpha-2b.

Drugs
Gaetano ScottoGioacchino Angarano

Abstract

The purpose of this randomized open-label study was to assess the efficacy of treatment with pegylated interferon-alpha-2a versus pegylated interferon-alpha-2b, both plus ribavirin, in inducing early and sustained virological response (EVR and SVR) in chronic hepatitis C non-responders. A total of 108 patients with chronic hepatitis C who were non-responders to previous combined therapy (standard interferon-alpha plus ribavirin for > or = 3 months) were enrolled and equally randomized into two groups in this intention-to-treat analysis. The patients exhibited similar baseline features. One group received subcutaneous pegylated interferon-alpha-2a 180 microg once weekly, while the other was treated with subcutaneous pegylated interferon-alpha-2b 1.5 microg/kg once weekly. Ribavirin 15 mg/kg/day was included in both protocols. Treatment duration for EVR was 12 weeks. Patients who demonstrated non-detectable hepatitis C virus (HCV) RNA or a > or = 2 log(10) reduction in viral load at week 12 continued therapy up to 48 weeks, with assessments every 3 months during a follow-up of 24 weeks. All patients in both groups completed the EVR study, then seven patients receiving pegylated interferon-alpha-2a and seven patients receiving peg...Continue Reading

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Citations

Nov 20, 2012·QJM : Monthly Journal of the Association of Physicians·C CooperE J Mills
Mar 26, 2013·European Journal of Gastroenterology & Hepatology·Umit B DoganSerkan Yalaki
May 19, 2009·Journal of Clinical Gastroenterology·Andrew Aronsohn, Nancy Reau
Dec 24, 2010·Journal of Clinical Pharmacy and Therapeutics·M Trapero-MarugánR Moreno-Otero
Mar 31, 2015·Annals of Hematology·Moshe TalpazRüdiger Hehlmann
Mar 4, 2014·The Cochrane Database of Systematic Reviews·Goran HauserChristian Gluud

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