Early Antibiotic Exposure and Adverse Outcomes in Preterm, Very Low Birth Weight Infants

The Journal of Pediatrics
Joseph B CanteyPablo J Sánchez

Abstract

To determine whether antibiotic use in the first 14 postnatal days in preterm, very low birth weight (birth weight of ≤1500 g) infants is associated with risk after 14 days of age for late-onset sepsis, necrotizing enterocolitis (NEC), or death after controlling for severity of illness using the Clinical Risk Index in Babies II score, and determine whether duration of antibiotic exposure was associated with risk of adverse outcomes. This retrospective cohort study included very low birth weight infants born at ≤326/7 weeks of gestation admitted to the neonatal intensive care unit from September 2010 to June 2014. Infants were excluded if they had major congenital anomalies or culture-proven sepsis, NEC, or death during the first 14 days of life. Antibiotic exposure was recorded as days of therapy and length of therapy in days. Of 374 infants, 70 (19%) had late-onset sepsis, NEC, or death after 14 days of age. The median number of antibiotic days of therapy and length of therapy were 5.5 and 3.0, respectively. In multivariate analysis after controlling for severity of illness, each antibiotic day of therapy was associated with a 1.24 times increased risk of sepsis, NEC, or death (OR, 1.24; 95% CI, 1.17-1.31). Risk was similar wh...Continue Reading

References

Feb 1, 1986·Pediatric Clinics of North America·M C Walsh, R M Kliegman
Jan 10, 2001·The Journal of Pediatrics·D K RichardsonS K Lee
Jun 5, 2003·Lancet·Gareth ParryUNKNOWN UK Neonatal Staffing Study Collaborative Group
Sep 27, 2003·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Leandro Cordero, Leona W Ayers
Dec 24, 2004·Journal of Perinatology : Official Journal of the California Perinatal Association·Alan R SpitzerMichael Kornhauser
Apr 29, 2005·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Joachim E Fischer
Apr 15, 2011·The Journal of Pediatrics·Vanaja N AlexanderMatthew J Bizzarro
Jul 26, 2011·The Journal of Pediatrics·Venkata S KuppalaKurt R Schibler
May 9, 2012·Archives of Disease in Childhood. Fetal and Neonatal Edition·Juliette C MadanPatricia L Hibberd
Dec 29, 2012·European Journal of Pediatrics·Jolita BekhofIrma H L M Van Straaten
Feb 19, 2013·Clinics in Perinatology·Roberto Murgas Torrazza, Josef Neu
Apr 10, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·P ShahS Patole
Dec 19, 2013·American Journal of Perinatology·Emily M HsiehUNKNOWN Best Pharmaceuticals for Children Act—Pediatric Trials Network
May 27, 2014·Infectious Disease Clinics of North America·Omar M Ibrahim, Ron E Polk
Sep 6, 2014·The Pediatric Infectious Disease Journal·Joseph B CanteyPablo J Sánchez
Dec 3, 2014·The Journal of Pediatrics·Silvia ArboleyaMiguel Gueimonde
May 1, 2015·Critical Care : the Official Journal of the Critical Care Forum·Michael W SjodingTheodore J Iwashyna
May 21, 2015·Pediatric Research·Ravi Mangal Patel, Patricia W Denning
Nov 2, 2016·JAMA : the Journal of the American Medical Association·Demetrios N Kyriacou, Roger J Lewis

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Citations

Apr 25, 2019·Minerva pediatrica·Mark A Underwood
Dec 28, 2019·Journal of the Pediatric Infectious Diseases Society·Prachi SinghRachel L Wattier
Mar 15, 2020·Journal of the Pediatric Infectious Diseases Society·Dustin D FlanneryKaren M Puopolo
Jul 23, 2020·The Journal of Perinatal & Neonatal Nursing
Aug 29, 2020·Pediatric Research·Mark A UnderwoodRavi M Patel
Jan 31, 2021·Maternal Health, Neonatology and Perinatology·Alaina K PylePablo J Sánchez
Feb 26, 2021·Pediatric Research·Mathilde LetouzeyUNKNOWN EPIPAGE-2 Working Group on Infections
Jul 21, 2021·American Journal of Perinatology·Ibukunoluwa C KaluJudith A Guzman-Cottrill
Aug 31, 2021·The Journal of Pediatrics·Siyuan JiangUNKNOWN REIN-EPIQ Study Group
Dec 1, 2021·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Alissa L MeisterKim Kopenhaver Doheny
Mar 2, 2019·Pediatrics·Joseph B Cantey, Adam L Hersh
May 25, 2020·The Journal of Pediatrics·Sagori MukhopadhyayUNKNOWN Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network

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