Early Appearance of Principal Symptoms of Kawasaki Disease is a Risk Factor for Intravenous Immunoglobulin Resistance

Pediatric Cardiology
Miyu TajimaJiro Kagawa

Abstract

It is difficult to accurately predict treatment resistance in Kawasaki disease (KD). Patients considered to be low-risk cases often develop resistance to intravenous immunoglobulin (IVIG). We herein examined whether information from the clinical course of KD could improve the prediction accuracy of a previously reported risk score. We retrospectively reviewed the clinical records of 100 KD patients. The clinical characteristics and laboratory data were compared between IVIG-sensitive and IVIG-resistant patients and also between patients with and without coronary artery aneurysm (CAA). The total incidence of IVIG resistance and CAA development was 34 and 13 %, respectively. Multiple regression analysis identified the early appearance of principal symptoms (≤day 2 of the illness) as a risk factor for IVIG resistance (OR 2.88, 95 % CI 1.11-7.44, p = 0.0041), whereas delayed IVIG administration (≥day 6) (OR 2.23, 95 % CI 0.66-7.64, p = 0.018) and IVIG resistance (OR 9.05, 95 % CI 2.27-36.10, p = 0.015) were independent predictors for CAA development. The addition of the first appearance day of principal symptoms into a previously reported scoring system improved its prediction accuracy for IVIG resistance. KD patients who had prese...Continue Reading

References

Nov 29, 2002·Pediatric Cardiology·K DurongpisitkulC Kangkagate
Mar 18, 2005·Pediatrics International : Official Journal of the Japan Pediatric Society·Mamoru AyusawaUNKNOWN Kawasaki Disease Research Committee
Aug 5, 2006·The Journal of Pediatrics·Kimiyasu EgamiToyojiro Matsuishi
Dec 25, 2008·Circulation·Hideaki Senzaki
May 22, 2010·Pediatrics International : Official Journal of the Japan Pediatric Society·Daisuke SudoYosikazu Nakamura
Feb 22, 2012·Pediatrics and Neonatology·Ho-Chang KuoKai-Sheng Hsieh
May 9, 2012·The Pediatric Infectious Disease Journal·Laura S CallinanErmias D Belay
May 25, 2012·Drugs·Nadia J C Luca, Rae S M Yeung
Oct 19, 2012·Current Opinion in Cardiology·Lori B DanielsJane C Burns
Jan 1, 2010·Annals of Vascular Diseases·Kei TakahashiShiro Naoe
Apr 16, 2013·The Pediatric Infectious Disease Journal·Yusuke ShiozawaJiro Kagawa
Jun 1, 2013·The Pediatric Infectious Disease Journal·Yu RuanXiaodong Zhao
Jun 19, 2013·International Journal of Rheumatic Diseases·Satoshi SatoAkinori Hoshika
Sep 18, 2013·Journal of Epidemiology·Yosikazu NakamuraHiroshi Yanagawa
Nov 20, 2013·Current Opinion in Rheumatology·Kei TakahashiYuki Yokouchi
Nov 28, 2013·International Journal of Pediatrics·Nathan Jamieson, Davinder Singh-Grewal
Jul 30, 2014·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Abigail MooreRichard Mayon-White

❮ Previous
Next ❯

Citations

Dec 10, 2015·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Ling LiuYan Ding
Nov 14, 2015·World Journal of Clinical Pediatrics·Jeong Jin Yu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aneurysm

Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.