PMID: 9439645Jan 24, 1998Paper

Early-appearing tumor-infiltrating natural killer cells play an important role in the nitric oxide production of tumor-associated macrophages through their interferon production

Cancer Immunology, Immunotherapy : CII
K AbeK Nomoto

Abstract

Both natural killer (NK) cells and macrophages are thought to be the main effectors responsible for early antitumor defense. In this study, we investigated the role of tumor-infiltrating NK cells in initiating nitric oxide (NO) production by tumor-associated macrophages (TAM). The in vivo depletion of NK cells prior to the i.p. inoculation of melanoma cells resulted in a significant decrease in the NO production of the TAM prepared from the peritoneal exudate cells (PEC). Such prior NK cell depletion also decreased the ability of TAM to show any antitumor activity in vitro. The addition of NG-monomethyl-L-arginine (Me-L-Arg) to the culture partially inhibited the ability of TAM to suppress the proliferation of melanoma cells and also decreased their cytolytic activity against melanoma cells. These results suggest that the TAM exhibited both cytostatic and cytolytic activities through their NO production. In an in vivo assay, the administration of Me-L-Arg permitted the more rapid growth of i.p. inoculated melanoma cells compared with the control. On the other hand, the decreased NO production of TAM, resulting from the prior NK cell depletion, was restored by the i.p. administration of interferon gamma (IFN gamma). In addition,...Continue Reading

Citations

Apr 27, 1999·Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie·S MnaimnehP Vincendeau
Apr 17, 2003·Journal of the National Cancer Institute·Jean-Philippe HerbeuvalChristian Genin
Dec 14, 2011·Clinical and Experimental Pharmacology & Physiology·C O TorelloM L S Queiroz
Oct 6, 2012·Journal of Immunotoxicology·Gerardo BottiMonica Cantile
Oct 22, 2008·Experimental and Molecular Pathology·Sally A duPre'Kenneth W Hunter
Oct 22, 2004·European Journal of Pharmacology·Marize C ValadaresMary L S Queiroz
Sep 24, 2004·International Journal of Cancer. Journal International Du Cancer·Maarten TimmersFilip Braet
Sep 11, 2008·Journal of Cancer Research and Clinical Oncology·Yi-Wei LiXiao-Wu Huang
Sep 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wiaam BadnPeter Siesjö
Dec 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ilia N BuhtoiarovAlexander L Rakhmilevich

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