Early Arrhythmic Events in Idiopathic Dilated Cardiomyopathy.

JACC. Clinical Electrophysiology
Pasquale LosurdoGianfranco Sinagra

Abstract

The study sought to provide an insight into the prevalence, characterization and possible reliable indicators of early sudden cardiac death/malignant ventricular arrhythmias (SCD/MVAs) in a large cohort of dilated cardiomyopathy (DCM). DCM generally affects young individuals and is characterized by an unpredictable prognosis with a non-negligible risk of SCD/MVAs, particularly in early stages of disease. From 1988 to 2014, 952 patients with DCM were consecutively included in the Heart Muscle Disease Registry of Trieste. Globally, 20 patients (2.1% of the overall population) experienced SCD/MVAs within the first 6 months after enrollment (primary endpoint). At baseline they showed a worse functional class (New York Heart Association functional class III to IV 42% vs. 22%, p = 0.038), a longer QRS complex duration (127 ± 41 ms vs. 108 ± 33 ms; p = 0.013) and a larger indexed left ventricular end-systolic volume (LVESVI) (82 ± 49 ml/m2 vs. 67 ± 34 ml/m2; p = 0.049), as compared to patients without early SCD/MVAs. Beta-blockers were less tolerated (59% vs. 83% in patients with no early SCD/MVAs; p = 0.008), mostly due to hemodynamic intolerance. At multivariate analysis, LVESVI (odds ratio [OR]: 1.012; 95% confidence interval [CI]:...Continue Reading

References

May 21, 2004·The New England Journal of Medicine·Alan KadishUNKNOWN Defibrillators in Non-Ischemic Cardiomyopathy Treatment Evaluation (DEFINITE) Investigators
Jan 22, 2005·The New England Journal of Medicine·Gust H BardyUNKNOWN Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT) Investigators
Jun 20, 2006·Journal of the American College of Cardiology·Alan KadishJoseph Levine
Mar 10, 2009·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Sherif F NaguehArturo Evangelisa
Apr 9, 2010·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Patrizio LancellottiUNKNOWN European Association of Echocardiography
Sep 4, 2012·Journal of Cardiac Failure·Richard SheppardUNKNOWN IMAC Investigators
Mar 7, 2013·JAMA : the Journal of the American Medical Association·Ankur GulatiSanjay K Prasad
Jan 22, 2014·Journal of the American College of Cardiology·Jeffrey J GoldbergerAlan H Kadish
Feb 4, 2014·Journal of the American College of Cardiology·James P Daubert, Robert K Lewis

❮ Previous
Next ❯

Citations

Sep 16, 2017·Circulation Research·Elizabeth M McNally, Luisa Mestroni
Apr 4, 2020·European Journal of Heart Failure·Gherardo FinocchiaroGianfranco Sinagra
May 22, 2020·European Journal of Heart Failure·Petar M Seferović, Marija M Polovina
Dec 23, 2017·European Journal of Heart Failure·Marco MerloGianfranco Sinagra
Jun 20, 2020·Heart Failure Reviews·Andrea Lorenzo VecchiMichele Senni
Jul 16, 2021·Heart Failure Reviews·Nicoletta OrphanouAris Anastasakis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antiarrhythmic Agents: Mechanisms of Action

Understanding the mechanism of action of antiarrhythmic agents is essential in developing new medications as treatment of cardiac arrhythmias is currently limited by the reduced availability of safe and effective drugs. Discover the latest research on Antiarrhythmic Agents: Mechanism of Action here.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Related Papers

Journal of the American College of Cardiology
Upasana TayalStuart A Cook
Journal of the American Heart Association
Ilaria PuggiaGianfranco Sinagra
Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
Aneta AleksovaGianfranco Sinagra
© 2022 Meta ULC. All rights reserved