Abstract
Although left ventricular assist devices (LVADs) have been commonly used for patients with cardiogenic shock after acute myocardial infarction (AMI), their effects on post-AMI prognosis remain to be elucidated. In this study, we aimed to explore the effects of an LVAD on left ventricular (LV) remodeling and function at the postinfarction stage in a swine model. AMI was induced by ligation of the circumflex artery or its branches for 120 min, followed by 120 min of reperfusion. In the assist group (n = 6), LVAD was initiated at 90 min after ischemia and was maintained for support until 120 min after reperfusion, whereas the control group (n = 6) received no support. LV pressure, volume, wall stress, and stroke work were all decreased by LVAD assistance at the ischemia and reperfusion stages, and blood pressure and cardiac output were maintained. All swine were studied 1 month after the procedure, and those in the assist group showed less increased end-diastolic volumes (assist vs. 57.9 ± 6.6 vs. 79.0 ± 6.7 mL, P = 0.032) and sphericity (assist vs. 1.33 ± 0.16 vs. 1.51 ± 0.12, P = 0.01), as well as improved ejection fractions (assist vs. 59.0 ± 7.8 vs. 42.3 ± 6.0%, P = 0.002). Furthermore, despite a presence of a similar initial ...Continue Reading
References
May 1, 1994·Circulation·K B GuptaD K Bogen
May 1, 1993·The American Journal of Cardiology·J R SchairerP D Stein
Sep 14, 2000·Journal of the American College of Cardiology·T A SanbornJ S Hochman
Oct 2, 2002·Journal of the American College of Cardiology·Benjamin M JacksonRobert C Gorman
Apr 8, 2003·Journal of the American College of Cardiology·Bart MeynsWillem Flameng
Aug 2, 2003·Clinical and Experimental Pharmacology & Physiology·Hiroyuki Suga
Oct 18, 2003·Journal of the American College of Cardiology·Eldrin F LewisUNKNOWN CARE Study
Sep 27, 2007·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Maurice RemmelinkJan Baan
Nov 15, 2008·Journal of the American College of Cardiology·Melchior SeyfarthAlbert Schömig
Feb 24, 2009·The Annals of Thoracic Surgery·James J PillaRobert C Gorman
Jul 21, 2009·European Heart Journal·Jin M ChengPatrick W Serruys
Nov 10, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Gregory M Fomovsky, Jeffrey W Holmes
Feb 15, 2011·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Dai KawashimaMinoru Ono
May 6, 2011·Expert Review of Medical Devices·Jane MaciverHeather J Ross
Aug 9, 2011·Artificial Organs·Stéphanie SchampaertMarcel C M Rutten
May 4, 2012·Circulation·Marek A DejaRobert H Jones
May 23, 2012·Artificial Organs·Michael BuerkeKarl Werdan
Nov 1, 2012·The Journal of Thoracic and Cardiovascular Surgery·Robert E MichlerUNKNOWN STICH Trial Investigators
Jun 15, 2013·Circulation·Navin K KapurRichard H Karas
Jul 3, 2013·The Annals of Thoracic Surgery·Jeremy R McGarveyJames J Pilla
Dec 20, 2013·Circulation·Alan S GoUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Citations
Mar 9, 2018·Journal of the American Heart Association·Shin WatanabeKiyotake Ishikawa
Sep 8, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Hai-Chao Han
Jan 24, 2019·Journal of Cardiovascular Translational Research·Jerry CurranRobert A Kloner
May 29, 2020·Artificial Organs·Mohamad Alkhouli
Mar 11, 2017·Artificial Organs·Angela T Hadsell, Paul S Malchesky
Aug 16, 2017·Experimental and Therapeutic Medicine·Xuelian WangXingui Guo
Nov 1, 2017·BioMed Research International·Xiaoqian YanJianye Zhou
Dec 14, 2018·F1000Research·Navin K KapurKiyotake Ishikawa
Apr 25, 2019·Journal of Cardiovascular Translational Research·Navin K KapurRichard Smalling
Nov 9, 2019·Journal of the American Heart Association·Natalia BricenoNavin K Kapur
Aug 30, 2020·Journal of Cardiovascular Translational Research·Satoshi MiyashitaKiyotake Ishikawa
May 31, 2018·Journal of Cardiovascular Translational Research·Nadjib HammoudiKiyotake Ishikawa
Feb 19, 2021·Future Cardiology·Malav J ParikhDavid Hw Wohns
Apr 16, 2020·Archives of Cardiovascular Diseases·Laurent BonelloFrançois Roubille
Aug 9, 2020·Journal of the American College of Cardiology·Lija SwainNavin K Kapur
Aug 9, 2020·Journal of the American College of Cardiology·Gerd Heusch, Tienush Rassaf