PMID: 9638340Jun 25, 1998Paper

Early atherosclerotic plaques in the aorta following cytomegalovirus infection of mice

Cell Adhesion and Communication
K BerencsiE Gönczöl

Abstract

We show here that BALB/c mice inoculated with murine cytomegalovirus (MCMV) express viral antigens in the endothelial and smooth muscle cells of the aortic wall, and that accumulation of inflammatory cells in the aortic lumen, similar to that seen in early atherosclerotic lesions in humans, colocalizes with the site of virus antigen expression. Immunosuppression of the mice at the time of virus infection increased the expression of viral antigens and the size of early atherosclerotic lesions in the intima. The percentage of the low-density lipoprotein cholesterol (LDL-C), the major lipid contributor to atherosclerotic plaques, was significantly increased in the serum of MCMV-infected mice, whether or not the mice were fed a high cholesterol diet. Human cytomegalovirus (HCMV) significantly increased the esterified cholesterol component of the total cholesterol in a human arterial smooth muscle cell line infected in vitro with HCMV. These results suggest that CMV infection is involved in two of the major mechanisms that lead to development of atherosclerosis, i.e., immune injury and high LDL-C.

References

Jan 1, 1991·Annals of the New York Academy of Sciences·R W Wissler
Dec 1, 1989·European Journal of Clinical Investigation·A H SpanC A Bruggeman
Jan 1, 1987·The Journal of Infectious Diseases·B L PetrieM E DeBakey
Dec 1, 1987·Atherosclerosis·B PaigenR A Williams
Jun 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·E P Benditt, J M Benditt
Sep 17, 1983·Lancet·J L MelnickM E DeBakey
Oct 1, 1984·The Journal of General Virology·E Gönczöl, S A Plotkin
Oct 1, 1995·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·J L MelnickM E DeBakey
Aug 1, 1995·The Journal of Infectious Diseases·L A CampbellJ T Grayston
Jul 18, 1995·Proceedings of the National Academy of Sciences of the United States of America·C C KuoE P Benditt
Oct 1, 1994·Journal of Virology·C A StoddartE S Mocarski
Aug 29, 1996·The New England Journal of Medicine·Y F ZhouS E Epstein

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Citations

Feb 16, 2010·Journal of Thrombosis and Thrombolysis·Milan PopovićYves Laumonnier
Nov 19, 2003·Microbes and Infection·Astrid KrmpoticStipan Jonjic
Nov 7, 1999·Antiviral Research·C A BruggemanG Nelissen-Vrancken
Sep 12, 2000·International Journal of Cardiology·A J Dal Canto, H W Virgin
Nov 21, 2002·Veterinary Microbiology·László Egyed, Ferenc Baska
Jun 19, 2002·Trends in Cardiovascular Medicine·Burkhard LudewigHans Hengartner
Oct 4, 2002·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Inge VliegenCatrien Bruggeman
Dec 26, 2008·International Journal of Epidemiology·Amanda M SimanekAllison E Aiello
Mar 5, 2009·Rheumatology·Cristina C BeliznaYehuda Shoenfeld
Oct 21, 2000·Journal of Clinical Pathology·S A MorréH W Niessen
Nov 5, 2008·Journal of Lipid Research·Linda K Curtiss, Peter S Tobias
Nov 26, 2008·Best Practice & Research. Clinical Rheumatology·Nicolò Pipitone, Carlo Salvarani
Feb 21, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Hannah A Valantine
Jan 3, 2006·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Frank R StassenCathrien A Bruggeman
Jan 17, 2002·Acta Microbiologica Et Immunologica Hungarica·Z KisE Gönczöl
Jun 6, 2002·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M Degré
Apr 13, 2000·Journal of Internal Medicine·A NicolettiG K Hansson
Feb 24, 2000·The Journal of Pathology·O J de BoerA E Becker
Sep 13, 2017·International Journal of Molecular Sciences·Sanguine ByunKi Won Lee
Apr 13, 2001·Medicinal Research Reviews·A MartinezC Perez
Jul 28, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Philippe KrebsBurkhard Ludewig
Feb 13, 2019·Cells·Young Jin JangSanguine Byun
May 1, 1999·The Pediatric Infectious Disease Journal·S A Plotkin
Jan 23, 1999·Current Opinion in Rheumatology·A J Dal Canto, H W Virgin
Mar 25, 2004·Journal of Leukocyte Biology·Burkhard LudewigElke Scandella
Feb 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·B LudewigR M Zinkernagel

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