Early auditory enrichment with music enhances auditory discrimination learning and alters NR2B protein expression in rat auditory cortex

Behavioural Brain Research
Jinghong XuXinde Sun

Abstract

Previous studies have shown that the functional development of auditory system is substantially influenced by the structure of environmental acoustic inputs in early life. In our present study, we investigated the effects of early auditory enrichment with music on rat auditory discrimination learning. We found that early auditory enrichment with music from postnatal day (PND) 14 enhanced learning ability in auditory signal-detection task and in sound duration-discrimination task. In parallel, a significant increase was noted in NMDA receptor subunit NR2B protein expression in the auditory cortex. Furthermore, we found that auditory enrichment with music starting from PND 28 or 56 did not influence NR2B expression in the auditory cortex. No difference was found in the NR2B expression in the inferior colliculus (IC) between music-exposed and normal rats, regardless of when the auditory enrichment with music was initiated. Our findings suggest that early auditory enrichment with music influences NMDA-mediated neural plasticity, which results in enhanced auditory discrimination learning.

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Citations

Nov 10, 2013·PloS One·Eino PartanenMinna Huotilainen
Oct 13, 2009·Progress in Neurobiology·Jess Nithianantharajah, Anthony J Hannan
Sep 10, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Anca AmagdeiAndrei C Miu
Apr 25, 2012·Annals of the New York Academy of Sciences·Teppo Särkämö, David Soto
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Oct 17, 2018·Scientific Reports·Andrew C KatsisMylene M Mariette
Jan 9, 2019·Frontiers in Behavioral Neuroscience·A Y Rosalie KühlmannJohannes Jeekel

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