PMID: 11345393May 10, 2001Paper

Early autonomic and repolarization abnormalities contribute to lethal arrhythmias in chronic ischemic heart failure: characteristics of a novel heart failure model in dogs with postmyocardial infarction left ventricular dysfunction

Journal of the American College of Cardiology
P B Adamson, E Vanoli

Abstract

Using a model of arrhythmias associated with ischemic left ventricular (LV) dysfunction, this study investigated autonomic and electrophysiologic mechanisms associated with sudden cardiac death (SCD) in chronic heart failure (HF). Left ventricular dysfunction from ischemic heart disease is associated with many instances of SCD. Electrophysiologic and autonomic derangements occur in HF, but their contribution to SCD risk is poorly understood. Sudden death risk was assessed in 15 dogs with a healed anterior myocardial infarction (MI) during submaximal exercise and brief acute circumflex ischemia. Left ventricular dysfunction was then induced by repetitive circumflex microembolization until LV ejection fraction reached 35%. Before embolization, six dogs were susceptible to SCD, and nine were resistant. Baroreflex sensitivity was lower in susceptible dogs (10 ms/mm Hg +/- 4 ms/mm Hg vs. 20 ms/mm Hg +/- 11 ms/mm Hg, p = 0.04). QT intervals from susceptible dogs were longer after MI (246 ms +/- 26 ms susceptible vs. 231 ms +/- 20 ms resistant, p < 0.001) and prolonged within eight weeks after LV dysfunction was established (from 246 ms +/- 26 ms to 274 ms +/- 56 ms, +11%, p < 0.01). Heart rate in susceptible dogs increased during tra...Continue Reading

References

Oct 1, 1990·Journal of the American College of Cardiology·S S HullP J Schwartz
Feb 1, 1973·Circulation Research·P J SchwartzA M Brown
Sep 27, 1984·The New England Journal of Medicine·J N CohnT Rector
Mar 1, 1994·Pacing and Clinical Electrophysiology : PACE·E Vanoli, P B Adamson
Mar 15, 1997·Journal of the American College of Cardiology·J S ShinbaneM M Scheinman
Dec 31, 1997·Journal of the American College of Cardiology·B F Uretsky, R G Sheahan
Apr 16, 1998·The American Journal of Cardiology·P J Schwartz
Nov 24, 1999·The American Journal of Cardiology·A Zivin, G H Bardy
Sep 12, 2000·Current Cardiology Reports·T H LeJemtel
Mar 1, 1992·Trends in Cardiovascular Medicine·J M WhartonH C Strauss

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Citations

Mar 28, 2007·Current Heart Failure Reports·Jeffrey Wing-Hong Fung, Cheuk-Man Yu
Sep 5, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Arun SridharCynthia A Carnes
Aug 19, 2007·Clinical Physiology and Functional Imaging·W NiewiadomskiG Cybulski
Feb 5, 2008·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Emilio VanoliPeter J Schwartz
Aug 18, 2004·Circulation·Philip B AdamsonUNKNOWN InSync III Model 8042 and Attain OTW Lead Model 4193 Clinical Trial Investigators
Jul 29, 2003·Journal of Cardiovascular Pharmacology·Philip B AdamsonPeter J Schwartz
Oct 5, 2016·Journal of Cardiovascular Development and Disease·Paula CamachoJia-Qiang He
Mar 22, 2019·Nature Reviews. Cardiology·Sebastian ClaussStefan Kääb
Sep 26, 2019·Frontiers in Cardiovascular Medicine·Joseph S Piktel, Lance D Wilson

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