Early bacterial infection of the pancreas and course of disease in cerulein-induced acute pancreatitis in rats

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
G ManesP Malfertheiner

Abstract

Bacterial infection of the pancreas aggravates the course of acute pancreatitis. Since bacterial translocation from the gut is likely to be an early event, in an animal model of pancreatitis, we investigated the effect of early bacterial supra-infection of the pancreas on the course of the disease. Six hours after the induction of acute pancreatitis in male Wistar rats (n = 180) by supramaximal stimulation with cerulein (or placebo in a control group), the animals were operated and a suspension of Helicobacter pylori, Escherichia coli or saline were introduced either in the pancreatic duct or interstitium (12 groups of 15 rats each); after 24 h, animals were killed and the following parameters analysed: macroscopic and histologic appearance of the pancreas (score), wet-to-dry weight ratio, pancreas trypsinogen activation peptide level, serum amylase, interleukin-6 and phospholipase A2 activity. All parameters were increased in rats with cerulein-induced pancreatitis in comparison to placebo. Interstitial and intraductal application of bacteria increased the pancreatic damage. This effect was more evident with the application of E. coli in both cerulein and placebo groups. Application of E. coli but not of H. pylori determined p...Continue Reading

References

Jun 1, 1990·The Journal of Infectious Diseases·J K XuJ Robinson
Feb 1, 1989·Klinische Wochenschrift·T J Nevalainen
Mar 1, 1980·Analytical Biochemistry·C Labarca, K Paigen
Nov 1, 1993·Gastroenterology·N YoshidaP R Kvietys
Dec 1, 1996·European Journal of Clinical Investigation·M NiliusP Malfertheiner
Jul 26, 2002·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Zygmunt WarzechaStanisław J Konturek
Oct 1, 1951·The American Journal of Digestive Diseases·H L POPPER, H NECHELES

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Citations

Apr 1, 2009·Current Therapeutic Research, Clinical and Experimental·Nara L HorstPaulo A Melo

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