Early BCG Vaccination, Hospitalizations, and Hospital Deaths: Analysis of a Secondary Outcome in 3 Randomized Trials from Guinea-Bissau

The Journal of Infectious Diseases
Frederik Schaltz-BuchholzerChristine Stabell Benn

Abstract

This study was performed to examine the effects of early BCG vaccination on the risk, cause, and severity of infant hospitalizations. The analysis included 3 trials randomizing low-weight neonates to early BCG vaccination (intervention) versus no BCG vaccination (usual practice in low-weight neonates, control), with hospitalizations as secondary outcome. Hospitalization data were collected at the pediatric ward of the National Hospital. Effects of BCG vaccination on hospitalization risk were assessed in Cox models providing overall and major disease-group incidence rate ratios (IRRs). Severity was assessed by means of in-hospital case-fatality rates and compared by group as cohort study risk ratios (RRs). Among 6583 infants (3297 in BCG group, 3286 controls), there were 908 infant hospitalizations (450 BCG, 458 controls) and 135 in-hospital deaths (56 BCG, 79 controls). The neonatal (28 days), 6-week, and infant (1-year) BCG versus control hospitalization IRRs were 0.97 (95% confidence interval [CI], .72-1.31), 0.95 (.73-1.24), and 0.96 (.84-1.10). Corresponding BCG versus control case-fatality rate RRs were 0.58 (95% CI, .35-.94), 0.56 (.35-.90), and 0.72 (.53-.99). BCG vaccination tended to reduce neonatal and infant sepsis h...Continue Reading

References

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Citations

Apr 26, 2020·Transactions of the Royal Society of Tropical Medicine and Hygiene·Christian N GoldingNelly A Amenyogbe
Jun 12, 2020·JAMA : the Journal of the American Medical Association·Lawrence O Gostin, Daniel A Salmon
Jul 22, 2020·The Journal of Clinical Investigation·Valerie Acm KoekenMihai G Netea
Jul 22, 2020·The Journal of Clinical Investigation·L Charlotte J de BreeMihai G Netea
May 8, 2020·Science Translational Medicine·Byron BrookNelly Amenyogbe
Nov 5, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Frederik Schaltz-BuchholzerChristine Stabell Benn
Dec 1, 2020·The Journal of Infectious Diseases·Marcel A BehrErwin Schurr
Dec 3, 2020·Urologic Oncology·John P SfakianosAmir Horowitz
Jan 22, 2021·Heliyon·Trine Mølbæk JensenThomas Nørrelykke Nissen
Feb 4, 2021·The Journal of Infectious Diseases·Marcel A BehrErwin Schurr
Jul 11, 2021·The Journal of Infectious Diseases·Sarah Prentice, Hazel M Dockrell
Sep 11, 2021·The Lancet Infectious Diseases·Christoph LangeAnna M Mandalakas

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