Early bioavailability of paracetamol after oral or intravenous administration

Acta Anaesthesiologica Scandinavica
P Holmér PetterssonJ Jakobsson

Abstract

Paracetamol is a peripherally acting analgesic commonly used in multimodal post-operative pain management to reduce the need for more potent analgesics with their unwanted side-effects. The dose and optimal galenical form for achieving analgesic concentrations is not well defined. The primary aim of this pilot project was to study the early bioavailability for two fixed doses of orally administrated paracetamol and one dose of intravenous propacetamol, all of which were given after minor surgery. Thirty-five patients undergoing day surgery were divided into five groups, seven patients each. Groups received either 1 g of an ordinary paracetamol tablet, 2 g of an ordinary paracetamol tablet, 1 g of a bicarbonate paracetamol tablet, 2 g of a bicarbonate paracetamol tablet or 2 g intravenously of prodrug propacetamol. We studied the plasma concentration of paracetamol during the first 80 min after administration. Within 40 min, intravenous propacetamol gave a median plasma paracetamol concentration of 85 micromol/l (range 65-161) and decreased thereafter. After oral administration, median plasma paracetamol concentration increased with increasing dose and time, but there were huge inter-individual differences at all time points stu...Continue Reading

References

Jul 1, 1992·British Journal of Clinical Pharmacology·B BannwarthA Gaucher
Jan 1, 1981·European Journal of Clinical Pharmacology·R A Seymour, M D Rawlins
Nov 1, 1993·Anesthesia and Analgesia·H Kehlet, J B Dahl
Jan 1, 1997·Paediatric Anaesthesia·B J Anderson, N H Holford
Mar 19, 1999·Acta Anaesthesiologica Scandinavica·R Korpela, K T Olkkola
Mar 14, 2000·Acta Anaesthesiologica Scandinavica·T W HahnM Rasmussen
Jul 6, 2000·European Journal of Clinical Pharmacology·T RygnestadF A Samdal
Jul 14, 2001·Clinical Pharmacology and Therapeutics·C D van der MarelD Tibboel
Jan 9, 2003·Best Practice & Research. Clinical Anaesthesiology·Frederic Camu, Caroline Vanlersberghe
Apr 8, 2003·Drugs·Allan B Shang, Tong J Gan
Oct 23, 2003·Methods and Findings in Experimental and Clinical Pharmacology·F J Sevilla-TiradoN Fernández-Hernando
Oct 29, 2003·Paediatric Drugs·Eva Kokinsky, Eva Thornberg

❮ Previous
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Citations

Sep 10, 2010·Der Anaesthesist·P K ZahnE M Pogatzki-Zahn
Sep 30, 2005·Anesthesiology·Edward MunsterhjelmPer H Rosenberg
Jun 23, 2005·International Anesthesiology Clinics·Girish P Joshi
Nov 9, 2007·Current Opinion in Anaesthesiology·Anil Gupta
Jun 3, 2009·European Journal of Anaesthesiology·Henning OhnesorgePeter H Tonner
Jun 2, 2011·Pediatric Emergency Care·Franz E BablGreta M Palmer
Sep 18, 2012·Anesthesia and Analgesia·Rozemarijn J van der VijverThijs Hendriks
Oct 12, 2007·Drugs·Josée GuindonPierre Beaulieu
Jun 10, 2010·Saudi Journal of Anaesthesia·Ben Gibbison, Stephen Michael Kinsella
Sep 1, 2012·Pain Management·Scott B GroudineDuane Ellsworth
Mar 20, 2010·European Journal of Clinical Pharmacology·Monique M de MaatHuibert H Ponssen
Apr 8, 2014·Biological & Pharmaceutical Bulletin·Pachaiyappan Sampath VenkatesanSigamany Masilamani Sakthivelan
Sep 6, 2014·Anesthesia Progress·Rodney N Nishimoto
Jun 2, 2011·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Howard S Smith
Feb 18, 2016·Current Pain and Headache Reports·Maunak V RanaD'Andra Davis
Jul 26, 2014·Pharmaceuticals·Jan G Jakobsson
Jan 9, 2013·Journal of Emergency Nursing : JEN : Official Publication of the Emergency Department Nurses Association·Jennifer L Kwiatkowski, Pamela L Walker
Jun 2, 2012·Pain Management Nursing : Official Journal of the American Society of Pain Management Nurses·Chris Pasero, Daphne Stannard
Nov 16, 2010·Anesthesiology Clinics·Jonathan S Jahr, Vivian K Lee
May 11, 2007·Best Practice & Research. Clinical Anaesthesiology·Narinder Rawal
May 11, 2007·Best Practice & Research. Clinical Anaesthesiology·Stephan A Schug, Andreas Manopas
Sep 22, 2006·Acta Anaesthesiologica Scandinavica·P Holmér PetterssonA Owall
Nov 13, 2007·Acta Anaesthesiologica Scandinavica·M SegerdahlJ Jakobsson
Dec 18, 2008·Anaesthesia·C D Oscier, Q J W Milner
Mar 15, 2005·Anesthesiology Clinics of North America·Girish P Joshi
Jan 15, 2013·International Journal of Surgery·Margareta Warrén StombergJan G Jakobsson
Dec 21, 2013·European Journal of Orthopaedic Surgery & Traumatology : Orthopédie Traumatologie·Mohammad Amin ZarePeyman Hafezimoghadam
Sep 26, 2014·Plastic and Reconstructive Surgery·Anil Gupta, Jan Jakobsson
Oct 16, 2007·Anaesthesia and Intensive Care·G M PalmerW Hardikar
Mar 17, 2010·Journal of Perioperative Practice·Claire Frampton, Jane Quinlan
Dec 17, 2010·British Journal of Neurosurgery·Shalini Nair, Vedantam Rajshekhar

❮ Previous
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