Early Bird Gets the Flu: What Should Be Done About Waning Intraseasonal Immunity Against Seasonal Influenza?

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Kunal J Rambhia, Milly T Rambhia

Abstract

Recently published studies highlight the growing evidence for waning immunity within a single influenza season among vaccinated individuals. However, the public health efforts to increase vaccination coverage has resulted in earlier administration of vaccines. We find this approach to be suboptimal, as the benefits of early vaccination could be lost during peak months of influenza activity. Immunity generated by influenza vaccines is a complex scientific issue with many contributing factors. We advocate for a nuanced approach to the seasonal vaccine program- one that considers duration of immunity as much as it considers coverage. As we strive for higher rates of vaccination, we must also improve the efficacy of the vaccine and the public health programs that are responsible for distributing and administering the vaccine.

References

Nov 4, 2010·Biosecurity and Bioterrorism : Biodefense Strategy, Practice, and Science·Kunal J RambhiaEric Toner
Feb 13, 2013·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·J CastillaUNKNOWN Network for Influenza Surveillance in Hospitals of Navarre
Feb 13, 2013·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·R G PebodyJ M Watson
Feb 13, 2013·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·E KisslingA Moren
Mar 19, 2013·Vaccine·Michael L Jackson, Jennifer C Nelson
Sep 24, 2013·BMC Infectious Diseases·Silvia Jiménez-JorgeUNKNOWN Spanish Influenza Sentinel Surveillance System
Nov 16, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Suzanne E OhmitArnold S Monto
Oct 7, 2015·PloS One·Nipaporn TewawongYong Poovorawan
Jan 27, 2016·HIV Medicine·E R GlinkaS T Johns
Mar 30, 2016·Vaccine·Alin GherasimUNKNOWN cycEVA team and the VEVA Working Group
Apr 29, 2016·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Esther KisslingUNKNOWN I-MOVE case–control study team
Sep 30, 2016·The New England Journal of Medicine·John J Treanor
Jan 1, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jill M FerdinandsEdward A Belongia
Aug 26, 2017·MMWR. Recommendations and Reports : Morbidity and Mortality Weekly Report. Recommendations and Reports·Lisa A GrohskopfDaniel B Jernigan
Sep 25, 2017·Vaccine·J Puig-BarberàUNKNOWN Valencia Hospital Network for the Study of Influenza and other Respiratory Viruses (VAHNSI, Spain)
Oct 19, 2017·Immunity·Catharine I PaulesAnthony S Fauci
Nov 8, 2017·Proceedings of the National Academy of Sciences of the United States of America·Seth J ZostScott E Hensley
Feb 16, 2018·MMWR. Morbidity and Mortality Weekly Report·Brendan FlanneryAlicia M Fry

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Citations

Jan 17, 2019·Journal of Travel Medicine·Barnaby E Young, Annelies Wilder-Smith
Nov 30, 2019·Advanced Materials·Haleigh B Eppler, Christopher M Jewell
May 24, 2020·Influenza and Other Respiratory Viruses·Aaron L WeinmanSteven Y C Tong
Jun 5, 2020·Journal of Infection Prevention·Masahide MatsushitaSeisho Takeuchi
Dec 20, 2020·The Journal of Infectious Diseases·Joanna KimballH Keipp Talbot
Jan 14, 2021·International Journal of Environmental Research and Public Health·Vaishnavi ParimalanathanSimon de Lusignan
Feb 1, 2022·Bulletin of Mathematical Biology·Irena PapstSteven H Strogatz

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