Early Blood-Brain Barrier Disruption after Mechanical Thrombectomy in Acute Ischemic Stroke

Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging
Zhong-Song ShiDavid S Liebeskind

Abstract

The impact of blood-brain barrier (BBB) disruption can be detected by intraparenchymal hyperdense lesion on the computed tomography (CT) scan after endovascular stroke therapy. The purpose of this study was to determine whether early BBB disruption predicts intracranial hemorrhage and poor outcome in patients with acute ischemic stroke treated with mechanical thrombectomy. We analyzed patients with anterior circulation stroke treated with mechanical thrombectomy and identified BBB disruption on the noncontrast CT images immediately after endovascular treatment. Follow-up CT or magnetic resonance imaging scan was performed at 24 hours to assess intracranial hemorrhage. We dichotomized patients into those with moderate BBB disruption versus those with minor BBB disruption and no BBB disruption. We evaluated the association of moderate BBB disruption after mechanical thrombectomy with intracranial hemorrhage and clinical outcomes. Moderate BBB disruption after mechanical thrombectomy was found in 56 of 210 patients (26.7%). Moderate BBB disruption was independently associated with higher rates of hemorrhagic transformation (OR 25.33; 95% CI 9.93-64.65; P < .001), parenchymal hematoma (OR 20.57; 95% CI 5.64-74.99; P < .001), and po...Continue Reading

References

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May 31, 2014·Stroke; a Journal of Cerebral Circulation·Zhong-Song ShiUNKNOWN Multi MERCI, TREVO, and TREVO 2 Investigators
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Citations

Dec 11, 2019·Stroke; a Journal of Cerebral Circulation·Magnus ThorénNiaz Ahmed
Jul 1, 2020·Frontiers in Neurology·Damir JanigroRamon Diaz-Arrastia
Jan 4, 2021·CNS Neuroscience & Therapeutics·Liyun WangJian Shen
Feb 27, 2021·Frontiers in Neurology·Guillaume CharbonnierThierry Moulin
Jun 14, 2021·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Wanchun ZhuChaohui Jing

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