PMID: 2492693Jan 1, 1989Paper

Early bronchopulmonary lesions in rat lung after normobaric 100% oxygen exposure and their evolution. A light and electron microscopic study

Virchows Archiv. A, Pathological Anatomy and Histopathology
A PorteM E Stoeckel

Abstract

In order to clarify the early phenomena involved in the lung reaction to hyperoxia, twenty adult male rats were exposed to 100% oxygen at 1 ATA. Morphological pulmonary lesions were detectable after only 24 h hyperoxia, and included vasoconstriction and perivascular oedema, bronchiolar constriction, and pericyte reaction. The lesions were irregularly scattered within the lung parenchyma and occurred preferentially in areas centred on bronchiolo-vascular stems. Even at the latest stages, pulmonary heterogeneity was obvious, from the coexistence of areas damaged at different times. Neuro-epithelial-bodies were found under the bronchiolar epithelium; the morphological aspect of the neuro-endocrine cells observed was consistent with hyperoxia-induced modulation of their secretory activity. Taken together, our findings show the speed of development of hyperoxia-induced pulmonary changes and raise some pathogenic considerations.

References

Aug 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·S D KoA S Narayanan
May 1, 1976·The American Journal of Physiology·R E KimballC E Cross
Jan 1, 1986·Annual Review of Physiology·D Shepro, B Dunham
Jan 1, 1986·Annual Review of Physiology·W A Pryor
Jan 1, 1986·Annual Review of Physiology·D JamiesonA Boveris
Aug 15, 1986·European Journal of Pharmacology·J R Castairs, P J Barnes
Jul 1, 1987·The American Review of Respiratory Disease·J G GarciaA B Malik
Aug 1, 1987·The American Review of Respiratory Disease·G H GurtnerJ R Michael
Mar 1, 1986·The Journal of Clinical Investigation·P B BittermanR G Crystal
Jun 1, 1974·The American Journal of Physiology·J D Crapo, D F Tierney
Feb 16, 1967·The New England Journal of Medicine·G NashH Pontoppidan
Jan 1, 1984·Annual Review of Biochemistry·R James, R A Bradshaw
Jan 1, 1982·Annual Review of Physiology·J W Ryan
Jan 1, 1982·Annual Review of Physiology·S I Said
Jan 1, 1982·Annual Review of Physiology·U S Ryan
May 1, 1984·Cell·C H Heldin, B Westermark
Aug 1, 1983·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·B HoussetA F Junod
Oct 13, 1983·The New England Journal of Medicine·W B DavisR G Crystal
Jun 1, 1981·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·E R Block, S A Stalcup

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Citations

Jan 1, 1989·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·A Burkhardt, H Cottier

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