Early cardiac changes induced by a hypercaloric Western-type diet in "subclinical" obesity

American Journal of Physiology. Heart and Circulatory Physiology
Nádia GonçalvesAdelino F Leite-Moreira

Abstract

"Obesity cardiomyopathy" effects have been widely described; however, the specific contribution of metabolic changes and altered adipokine secretion are still uncharacterized. Moreover, a diagnosis based on body mass index might not be the most accurate to identify increased adiposity and its outcomes. In this study, we aimed to determine the impact of a Western-type diet [hypercaloric diet (HCD)] ingestion on biventricular structure and function, as well as the metabolic and endocrine changes that occur before the establishment of overt obesity. Wistar rats were fed for 6 wk with a regular diet or HCD. At the end of the protocol, metabolic tests, cardiac structure, and functional evaluation were performed, and blood and tissue samples collected to perform histological, molecular biology, and functional studies. The animals that ingested the HCD presented increased adiposity and larger adipocyte cross-sectional area, but similar body weight compared with the regular diet group. At the cardiac level, HCD induced biventricular cardiomyocyte hypertrophy, fibrosis, increased stiffness, and impaired relaxation. Galectin-3 plasma expression was likewise elevated in the same animals. The nutritional modulation also altered the secreto...Continue Reading

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Citations

May 20, 2016·International Journal of Cardiology·N GonçalvesI Falcão-Pires
Dec 5, 2017·Oxidative Medicine and Cellular Longevity·Evaristo Fernández-SadaGerardo García-Rivas
Mar 17, 2017·Circulation. Cardiovascular Imaging·John S Gottdiener, Willem J Kop
Jun 8, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Jorge Espinoza-DeroutTheodore C Friedman
Dec 24, 2019·Annals of the New York Academy of Sciences·John R BrachtDeborah J Clegg
May 14, 2020·Arquivos brasileiros de cardiologia·Silvio Assis de Oliveira-JuniorPaula Felippe Martinez
Mar 27, 2018·Oxidative Medicine and Cellular Longevity·Rodrigo L CastilloCatalina Carrasco-Pozo
Jul 1, 2020·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Kevin BoldtWalter Herzog
Oct 28, 2020·Histochemistry and Cell Biology·Christian MühlfeldJulia Schipke
Mar 12, 2021·The Journal of Nutritional Biochemistry·Danielle Fernandes VileigasAntonio Carlos Cicogna
May 1, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Mary C WingardKrishna Singh

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