Early cardiotoxicity of Hydroxychloroquine

La Revue de médecine interne
Y ZerbibJ Schmidt

Abstract

Hydroxychloroquine (HCQ) is most frequently used in the treatment of systemic inflammatory diseases. Cardiac complications of anti-malarial drugs are uncommon, and most of the time are the result of a long-term exposition. In this case, cardiotoxicity is the consequence of the lysosomal dysfunction and the result of intracytoplasmic granular material inclusions. We report a 77-year-old woman who presented a very early and reversible cardiotoxicity, probably related to the quinidine like effect of the HCQ, 10 days after initiation of therapy for Whipple endocarditis. We discuss the different mechanisms of cardiotoxicity of anti-malarial drugs and their clinical manifestations.

Citations

Jun 3, 2018·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Clotilde ChatreYves-Marie Pers
Dec 15, 2020·American Journal of Clinical Pathology·Urooba NadeemJefree J Schulte

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