Early cardiovascular manifestations in children and adolescents with autosomal dominant polycystic kidney disease: a single center study

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Vasiliki KaravaGeorges Deschênes

Abstract

This study aims to describe the cardiovascular manifestations in children with autosomal dominant polycystic kidney disease (ADPKD) and detect their relation with kidney disease and type of gene mutation. Twenty-one patients (7 to 19 years old) were included. Cardiovascular evaluation involved blood pressure (BP), indexed left ventricular mass (LVMI), pulse wave velocity (PWV), and carotid intima media thickness (cIMT) measurement. Patients were classified according to percentile reference values of these parameters in healthy children. The 95th percentile was the highest level of normal values. Glomerular filtration rate (GFR) and microalbuminuria were also measured. Antihypertensive treatment, large LVMI, high PWV, and increased cIMT were observed in 6 (28.6%), 2 (9.5%), 4 (19%), and 8 (38.1%) patients respectively. Antihypertensive treatment was not associated with either high PWV or increased cIMT. Linear correlation was noticed between LVMI and PWV (r2 = 0.243, p = 0.023) and also between LVMI and cIMT (r2 = 0.203, p = 0.041). The median age of patients with high PWV, increased cIMT, and large LVMI was 9.5, 13, and 18 years old. GFR was normal in all patients. Patients with increased cIMT presented higher levels of urine m...Continue Reading

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Citations

May 31, 2020·IUBMB Life·Mayssa AbdelwahedNeïla Belguith
Sep 8, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Karolis AzukaitisRukshana Shroff
Jun 28, 2019·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Matko MarlaisPaul Jd Winyard
Jan 13, 2021·Néphrologie & thérapeutique·Mouad HamzaouiDominique Guerrot
Feb 9, 2021·Journal of Pediatric Genetics·Dorota WicherIrena Jankowska
Mar 8, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Charlotte GimpelDjalila Mekahli

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