Early cerebral oxygen extraction and the risk of death or sonographic brain injury in very preterm infants

The Journal of Pediatrics
Kiran Kumar BalegarC C Andersen

Abstract

To evaluate the relationship between cerebral fractional tissue oxygen extraction (cFTOE), a measure of oxygen delivery-consumption equilibrium, and the risk of early poor outcome in very preterm infants. Cerebral blood flow, tissue oxygenation index (by near-infrared spectroscopy), and arterial oxygen content were measured, and cerebral oxygen delivery, consumption, and cFTOE were calculated at 3 intervals in the first 72 hours of life in infants ≤ 30 weeks gestational age (GA). A receiver operating characteristic curve was derived with an a priori defined dichotomized outcome of good or poor, defined as death or sonographic brain injury (grade ≥ II intraventricular hemorrhage) by day 7. Seventy-one infants were enrolled, with a mean (SD) GA of 27 (2) weeks. cFTOE demonstrated better discrimination for the study outcome at <24 hours of age than at 48 or 72 hours of age (P = .01). The area under the curve for cFTOE at the initial measurement was no different from that for GA alone (0.87; 95% CI, 0.77-0.95 vs 0.81; 95% CI, 0.69-0.92), but the combined measure of cFTOE and GA had better discrimination (0.96; 95% CI, 0.91-1.0) than either cFTOE (P = .03) or GA (P = .016) alone. A cFTOE of 0.4 had a sensitivity of 82% and specifici...Continue Reading

References

Apr 1, 1989·Archives of Disease in Childhood·D B ShortlandM I Levene
Nov 1, 1994·European Journal of Pediatrics·J U GrönlundI A Välimäki
Nov 1, 1996·Archives of Disease in Childhood. Fetal and Neonatal Edition·N Evans, M Kluckow
Jun 22, 1999·Archives of Disease in Childhood. Fetal and Neonatal Edition·J H MeekJ S Wyatt
May 5, 2000·Archives of Disease in Childhood. Fetal and Neonatal Edition·M Kluckow, N Evans
Jun 30, 2000·Journal of Perinatal Medicine·M GleissnerS Avenarius
Oct 13, 2001·Developmental Neuroscience·G Greisen, K Børch
May 3, 2002·Pediatrics·Christina HoeckerOtwin Linderkamp
Oct 23, 2002·Archives of Disease in Childhood. Fetal and Neonatal Edition·G NaulaersH Devlieger
Jun 5, 2003·Lancet·Gareth ParryUNKNOWN UK Neonatal Staffing Study Collaborative Group
Nov 7, 2003·Archives of Disease in Childhood. Fetal and Neonatal Edition·D A OsbornM Kluckow
Apr 30, 2004·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Tiina OjalaTuula Aärimaa
Mar 4, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Christopher M KissackA Michael Weindling
Sep 9, 2006·Seminars in Fetal & Neonatal Medicine·Gorm Greisen
May 23, 2007·Pediatric Research·Janet S SoulAdré J du Plessis
Oct 22, 2008·Pediatrics·Catherine LimperopoulosAdré J du Plessis
Aug 4, 2009·Intensive Care Medicine·Flora Y WongAdrian M Walker
Aug 14, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P Ellen GrantMaria Angela Franceschini

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Citations

Nov 26, 2014·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Katherine M Newnam
Aug 13, 2015·Archives of Disease in Childhood. Fetal and Neonatal Edition·Michael J StarkChad C Andersen
May 3, 2015·Seminars in Fetal & Neonatal Medicine·Beena G SoodJosef Cortez
Nov 26, 2015·Neural Regeneration Research·Christopher LawtonCesar V Borlongan
Apr 17, 2015·Archives of Disease in Childhood. Fetal and Neonatal Edition·C C AndersenM J Stark
May 5, 2017·Journal of Perinatology : Official Journal of the California Perinatal Association·P KorčekG Naulaers
Nov 10, 2016·Archives of Disease in Childhood. Fetal and Neonatal Edition·Stuart B HooperGraeme R Polglase
Feb 7, 2018·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Felix NeunhoefferJörg Michel
Dec 2, 2017·Developmental Medicine and Child Neurology·Robert GalinskyAlistair J Gunn
Sep 5, 2017·The Cochrane Database of Systematic Reviews·Simon Hyttel-SorensenChristian Gluud
Jan 8, 2016·Journal of Perinatology : Official Journal of the California Perinatal Association·M El-DibH Aly
Jun 20, 2018·The Journal of Physiology·Yvonne A EibyBarbara E Lingwood
Oct 23, 2018·Clinical and Experimental Pharmacology & Physiology·Barbara E LingwoodIan M R Wright
Feb 8, 2019·Archives of Disease in Childhood. Fetal and Neonatal Edition·Aidan J KashyapRyan J Hodges
Feb 8, 2019·Archives of Disease in Childhood. Fetal and Neonatal Edition·Philip L J DeKoninckRyan J Hodges
Jul 1, 2019·Archives of Disease in Childhood. Fetal and Neonatal Edition·Isabel Hui Xuan NgTopun Austin
Mar 30, 2017·Frontiers in Pediatrics·Laura Marie Louise DixPetra Maria Anna Lemmers
Oct 8, 2019·British Journal of Haematology·Maria Saito-BenzMary J Berry
Apr 11, 2019·Journal of Paediatrics and Child Health·Lydia M L KennedyMichael J Stark
May 10, 2018·Journal of Perinatology : Official Journal of the California Perinatal Association·Halana V WhiteheadAmit M Mathur
Jan 4, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Matthew W HarerRyan M McAdams
Apr 17, 2020·Early Human Development·Peter KorčekZbyněk Straňák
Mar 6, 2021·Journal of Perinatology : Official Journal of the California Perinatal Association·Catherine C CibulskisAmit M Mathur
Jun 8, 2021·Frontiers in Pediatrics·Maria Luisa TatarannoManon J N L Benders

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