Early changes in cardiovascular structure and function in adolescents with type 1 diabetes.

Cardiovascular Diabetology
Timothy J BradleyDavid Z I Cherney

Abstract

Children with type 1 diabetes (T1D) are at higher risk of early adult-onset cardiovascular disease. We assessed cardiovascular structure and function in adolescents with T1D compared with healthy controls and the relationships between peripheral vascular function and myocardial parameters. 199 T1D [14.4 ± 1.6 years, diabetes duration 6.2 (2.0-12.8) years] and 178 controls (14.4 ± 2.1 years) completed endothelial function by flow mediated vasodilatation (FMD), arterial stiffness using pulse wave velocity (PWV) along with M-mode, pulse wave and tissue Doppler, and myocardial deformation echocardiographic imaging. Systolic (113 ± 10 vs. 110 ± 9 mmHg; p = 0.0005) and diastolic (62 ± 7 vs. 58 ± 7 mmHg; p < 0.0001) blood pressures, carotid femoral PWV and endothelial dysfunction measurements were increased in T1D compared with controls. Systolic and diastolic left ventricular dimensions and function by M-mode and pulse wave Doppler assessment were not significantly different. Mitral valve lateral e' (17.6 ± 2.6 vs. 18.6 ± 2.6 cm/s; p < 0.001) and a' (5.4 ± 1.1 vs. 5.9 ± 1.1 cm/s; p < 0.001) myocardial velocities were decreased and E/e' (7.3 ± 1.2 vs. 6.7 ± 1.3; p = 0.0003) increased in T1D. Left ventricular mid circumferential strain...Continue Reading

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Citations

Apr 13, 2017·Journal of cardiovascular ultrasound·Chi Young Shim
Nov 13, 2018·Antioxidants & Redox Signaling·Lorna J DanielsLea M D Delbridge
Oct 26, 2018·PloS One·Martin HeierKnut Dahl-Jørgensen
Jan 15, 2017·Cardiovascular Diabetology·Jason Kar Sheng LewRajesh Katare
Jul 21, 2017·Archives of Endocrinology and Metabolism·Lúcia Helena Bonalume TacitoJuan Carlos Yugar-Toledo
Jul 16, 2020·International Journal of Molecular Sciences·Ida PastorePaolo Fiorina
Jul 2, 2021·Frontiers in Endocrinology·Sophie I MavrogeniGeorge Chrousos

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Clinical Trials Mentioned

NCT01581476

Software Mentioned

Vascular Tools
EchoPAC
AdDIT
SAS

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