Early changes in experimental osteoarthritis using the Pond-Nuki dog model: technical procedure and initial results of in vivo MR imaging

European Radiology
Martin LibicherWolfram Wenz

Abstract

The purpose of this study was to prove the feasibility of combining in vivo MR imaging with the Pond-Nuki animal model for the evaluation of osteoarthritis. In an experimental study, 24 beagle dogs underwent transection of the anterior cruciate ligament of the left leg (modified Pond-Nuki model). The dogs were randomly assigned into four groups and examined by MRI after 6, 12, 24 and 48 weeks. MR imaging of both knees was performed under general anesthesia with the contralateral joint serving as control. In group 1 (6 weeks postoperatively), the first sign detected on MRI was subchondral bone marrow edema in the posteromedial tibia. After 12 weeks, erosion of the posteromedial tibial cartilage could be observed, followed by meniscus degeneration and osteophytosis after 24 and 48 weeks. The contralateral knee joint showed transient joint effusion, but no significant signs of internal derangement (P<0.001). By combining in vivo MR imaging with the Pond-Nuki model, it is possible to detect early signs of osteoarthritis. The first sign was posteromedial subchondral bone marrow edema in the tibia followed by progressive cartilage degeneration and joint derangement. The in vivo model therefore seems to be suitable for longitudinal st...Continue Reading

References

Feb 1, 1977·The Journal of Bone and Joint Surgery. British Volume·C McDevittH Muir
Jul 1, 1973·Annals of the Rheumatic Diseases·M J Pond, G Nuki
Jan 1, 1982·Current Topics in Pathology. Ergebnisse Der Pathologie·M E Adams, M E Billingham
Oct 21, 2000·Investigative Radiology·D BursteinM L Gray
Nov 10, 2001·European Radiology·K NakanishiH Nakamura
Jun 4, 2002·European Radiology·H Imhof, M Fuchsjäger
Oct 22, 2002·AJR. American Journal of Roentgenology·Andrew H SoninStephen Hatem
Dec 25, 2002·Journal of Magnetic Resonance Imaging : JMRI·Ravinder Reddy RegatteRavinder Reddy
Mar 29, 2003·Clinical Radiology·A GuermaziH K Genant
Jul 2, 2003·European Radiology·Ali GuermaziHarry K Genant
Oct 2, 2003·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Garry E GoldDavid G Disler

❮ Previous
Next ❯

Citations

Aug 22, 2007·Current Opinion in Orthopaedics·Braden C FlemingPaul D Fadale
Jan 18, 2013·Arthritis·Martin H GregorySeth L Sherman
Dec 29, 2013·American Journal of Veterinary Research·Giovanni TremoladaAntonio Pozzi
Mar 23, 2012·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Sandro KohlStefan Eggli
Feb 16, 2008·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Hiromi OdaSeizo Yamamoto
Sep 23, 2009·The Journal of Small Animal Practice·E BarrettK Bradley
Dec 13, 2006·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Sandra MartigJohann Lang
Oct 7, 2008·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Laurent BlondIan D Robertson
Apr 25, 2016·Best Practice & Research. Clinical Rheumatology·M Marenzana, G Vande Velde
Aug 19, 2007·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Kevin R WinegardnerRory J Todhunter
Mar 3, 2009·Annals of the New York Academy of Sciences·Jian Zhao, Thomas M Link
Mar 28, 2007·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Sandra MartigJohann Lang
Jun 20, 2008·Veterinary Surgery : VS·Andrew P MooresChristopher R Lamb
Jun 5, 2010·Veterinary Surgery : VS·Dominic J Marino, Catherine A Loughin
Sep 2, 2008·Osteoarthritis and Cartilage·M BouchguaS Laverty
Feb 24, 2007·European Journal of Radiology·F M Vanhoenacker, A Snoeckx
Mar 2, 2010·Osteoarthritis and Cartilage·B C FlemingG A Tung
Oct 21, 2016·Polish Journal of Veterinary Sciences·A PrzeworskiJ Głodek
Dec 3, 2016·BMJ Open Sport & Exercise Medicine·Marlous KasteleinEdwin H G Oei
Dec 2, 2010·Nature Reviews. Rheumatology·Dick Heinegård, Tore Saxne
Apr 10, 2019·The Journal of the American Academy of Orthopaedic Surgeons·Mitchell R Klement, Peter F Sharkey
Dec 10, 2020·Scientific Reports·Yehan FangJianping Lin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.