Early changes in hemoglobin and hematocrit levels after packed red cell transfusion in patients with acute anemia

Transfusion
J I ElizaldeJ Terés

Abstract

Equilibration of hemoglobin concentration after transfusion has been estimated to take about 24 hours, but some studies have shown that earlier measurements reflect steady-state values in persons who have not bled recently. This study was aimed at assessing the changes over time in hemoglobin concentration after transfusion in acutely anemic patients because of recent bleeding. Thirty-two normovolemic patients recovering from an acute bleeding episode who were no longer thought to be bleeding and who received a 2-unit red cell transfusion were studied. At baseline and 15, 30, 60, and 120 minutes and 24 hours after transfusion, hemoglobin concentration and hematocrit values were measured. The administration of 2 units of packed red cells elicited a 24-hour increase of 22.4 +/- 6.8 g per L in hemoglobin concentration. Hemoglobin values were not different at any of the defined posttransfusion times. Hematocrit levels experienced similar changes over time. Agreement between 15-minute and 24-hour values was excellent, as only 6 percent of patients exhibited a clinically significant difference (> 6 g/L) between the hemoglobin measurements. Hemoglobin and hematocrit values rapidly equilibrate after transfusion in normovolemic patients...Continue Reading

Citations

Nov 9, 2005·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Miguel GlatsteinShaul Dollberg
May 15, 2007·The Journal of Trauma·Johanna M M NijboerMaarten W N Nijsten
Dec 7, 2010·The Journal of Trauma·Joseph A PoslusznyRichard L Gamelli
Nov 24, 2005·Gastroenterology Clinics of North America·Eric Esrailian, Ian M Gralnek
Mar 3, 2006·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Joseph D Sweeney
Jan 19, 2017·Journal of Veterinary Emergency and Critical Care·Kate S FarrellLauren A Sullivan
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Aug 31, 2018·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Allan DoctorUNKNOWN Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PAL
Sep 28, 2018·Transfusion·Ilyas SahinJoseph D Sweeney
Jul 5, 2019·Transfusion·Matthew S KarafinUNKNOWN NHLBI Recipient Epidemiology and Donor Evaluation (REDS)-III Study
Oct 30, 2020·Journal of Veterinary Emergency and Critical Care·Jennifer L MorrisTamera L Brabson
Jul 5, 2002·The American Journal of Emergency Medicine·Yitzchak A GlickJames Aiello

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