Early changes in tests of peripheral nerve function during oxaliplatin treatment and their correlation with chemotherapy-induced polyneuropathy symptoms and signs

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
T KrøigårdS H Sindrup

Abstract

Assessment of the severity of chronic peripheral neuropathy during oxaliplatin treatment is based on symptoms. Efforts to adjust the total dose of oxaliplatin to prevent severe neuropathy can be complicated by the worsening of neuropathy symptoms following treatment. Objective measures of the structure and function of peripheral nerves during early phases of treatment may aid in determining the optimal oxaliplatin dose in individual patients. Intraepidermal nerve fibre density (IENFD) has been suggested as an early marker of peripheral neuropathy. Sixty patients were examined before treatment and following 25% and 50% of the total planned oxaliplatin dose. Fifty-five of them were also examined at completion of chemotherapy and 6 months later. IENFD in skin biopsies from the distal leg, nerve conduction studies and quantitative sensory testing at the dorsum of the foot were performed. Forty-six healthy subjects were examined at baseline and after 6 and 52 weeks for comparison. Intraepidermal nerve fibre density was not reduced during treatment. Sural nerve amplitude and conduction velocity, vibration detection thresholds, mechanical detection threshold and cold detection threshold were significantly reduced during treatment. Com...Continue Reading

References

Apr 24, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·I S J MerkiesUNKNOWN Inflammatory Neuropathy Cause and Treatment (INCAT) group
Jan 23, 2003·Brain : a Journal of Neurology·Chun-Liang PanSung-Tsang Hsieh
Jun 17, 2005·Journal of the Peripheral Nervous System : JPNS·Peter J DyckRaul Espinosa
Jul 11, 2006·European Neurology·Alberto PietrangeliCarlo Garufi
Jan 16, 2007·Muscle & Nerve·T UmapathiYiong Huak Chan
Nov 3, 2010·Journal of the Peripheral Nervous System : JPNS·Giuseppe LauriaIngemar S J Merkies
Apr 12, 2011·The Oncologist·Susanna B ParkMatthew C Kiernan
Aug 26, 2011·Neurology·A Z BurakgaziMichael Polydefkis
Mar 20, 2012·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Barbara K BennettDavid Goldstein
Aug 2, 2013·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Cindy TofthagenYating Yeh
Jan 28, 2014·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·T KrøigårdS H Sindrup
Aug 5, 2015·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Thomas KrøigårdSøren H Sindrup

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Citations

Mar 24, 2020·F1000Research·Richard Gordon-Williams, Paul Farquhar-Smith
Apr 6, 2021·Journal of Neuromuscular Diseases·Thomas KrøigårdSøren H Sindrup
Jun 3, 2021·International Journal of Environmental Research and Public Health·Hsing-Wei HungShu-Ching Chen
Jun 19, 2021·The Ocular Surface·Jeremy Chung Bo ChiangMaria Markoulli
Aug 7, 2021·Journal of Personalized Medicine·Roser VelascoAndreas A Argyriou
Aug 11, 2021·Muscle & Nerve·Franco GemignaniGiovanni Pavesi
Oct 17, 2021·Oncology and Therapy·Jamie BurgessUazman Alam

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