PMID: 9948Sep 1, 1976

Early changes in the arterial wall of chickens fed a cholesterol diet

Atherosclerosis
M ChvapilC D Eskelson

Abstract

A total of 160 1-2 day old chickens were fed a 2% cholesterol diet for a period of 8 to 42 days and compared with an equal number of controls. Aortas were analyzed for various indexes of reactivity of connective tissue, cholesterol content and scanning electron microscopy (SEM) characteristics of the endothelial lining. Cholesterol feeding for a period up to 6 weeks resulted in doubling the level of serum cholesterol. It was, however, without effect on the activity of prolyl hydroxylase, lysyl oxidase, collagenase and collagen content in the aortic wall. As early as 3 weeks of feeding significant changes occurred in total and esterified cholesterol content. At the same time endothelial cells were characteristically contracted with several long cytoplasmic elongations and protrusions. A significant decrease of activity of the above enzymes was found in aortic tissue with increased age of the chicken. Collagen content in aortas increased with age of chickens. It is concluded that cholesterol as an atherogenic agent induces marked changes in endothelial cells and lipids of chicken aorta at earlier periods, prior to the activation of connective tissue.

References

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Citations

Jun 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·R C SiegelJ M Aguiar
Nov 1, 1979·Archives of Environmental Health·M ChvapilJ A Owen
Sep 1, 1994·The British Journal of Dermatology·H KobayashiA Ooshima
Nov 1, 1989·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·K E TaylorC K Zarins
Sep 17, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Ruud A Bank, Victor W M van Hinsbergh
Sep 17, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Cristina RodríguezLina Badimon
Oct 17, 2019·Biomolecules·José Martínez-GonzálezCristina Rodríguez
Nov 1, 1995·The British Journal of Dermatology·M ChanokiA Ooshima
Jan 1, 1980·Acta Medica Scandinavica. Supplementum·E J Bowie, V Fuster

Related Concepts

Metazoa
Ascending Aorta Structure
Descending Aorta
Arteries
Arteriosclerosis
Epicholesterol
Cholesterol, Dietary
Protein-Lysine 6-Oxidase
Scanning Electron Microscopy
Procollagen-Proline Dioxygenase

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