Early changes in the functions of cardiac sarcoplasmic reticulum in volume-overloaded cardiac hypertrophy in rats

Journal of Molecular and Cellular Cardiology
Y HisamatsuM Matsuzaki

Abstract

By sequestering activator calcium, the sarcoplasmic reticulum (SR) plays the central role in the excitation-contraction (E-C) cycle of cardiac muscle. Hence, functional changes in the SR in diseased myocardium might critically determine its mechanical characteristics. Previously, we demonstrated that both Ca2+ release and uptake were increased in SR isolated from hearts showing compensatory left ventricular (LV) hypertrophy taken from pressure-overloaded rats. However, it has not been elucidated whether such alterations also occur in the volume-overloaded myocardium. Rats in which volume-overloaded hypertrophy had been induced by aortocaval shunt 12 weeks prior to the investigation were compared to sham-operated controls in terms of SR Ca2+ uptake and release, and density of Ca2+ releasing channels (ryanodine receptors, RyR). Isometric tension and intracellular Ca2+ transients were also measured using the bioluminescent Ca2+ indicator, aequorin, in isolated LV papillary muscles. The extent of hypertrophy was verified by measuring the ratio of biventricular weight to body weight. In vivo, the aortocaval shunt rats showed normal LV contractility and slightly depressed LV relaxation, indicating a compensatory (adaptive) stage of L...Continue Reading

Citations

Mar 15, 2000·Journal of Pharmacological and Toxicological Methods·R Gaspo
Jul 24, 1998·Journal of Cardiovascular Pharmacology·M YanoM Matsuzaki
Feb 17, 2007·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Andrea P Babick, Naranjan S Dhalla
Mar 24, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Takashi SatoMasunori Matsuzaki
Feb 1, 2003·Japanese Heart Journal·Antonio Carlos CicognaMarina Politi Okoshi
Oct 21, 2000·Journal of Molecular and Cellular Cardiology·G WölkartF Brunner
Mar 3, 1999·Clinical and Experimental Hypertension : CHE·X LiuN S Dhalla
Dec 12, 2012·Journal of Molecular and Cellular Cardiology·Anuradha GuggilamPamela A Lucchesi
May 17, 2006·Journal of Cardiovascular Pharmacology and Therapeutics·Naranjan S DhallaRamesh K Goyal
Sep 29, 2000·American Journal of Physiology. Heart and Circulatory Physiology·M YanoM Matsuzaki
Feb 9, 2000·American Journal of Physiology. Heart and Circulatory Physiology·T TanigawaM Matsuzaki
Aug 26, 2021·Scientific Reports·Tereza HavlenovaVojtech Melenovsky

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