Early changes of hypothalamic angiotensin II receptors expression in gestational protein-restricted offspring: effect on water intake, blood pressure and renal sodium handling

Journal of the Renin-angiotensin-aldosterone System : JRAAS
Marcelo Cardoso de LimaJ A R Gontijo

Abstract

The current study examines changes in the postnatal hypothalamic angiotensin receptors by maternal protein restriction (LP), and its impact on in uteri programming of hypertension in adult life. The data show that LP male pup body weight was significantly reduced when compared to that of control (NP) pups. Also, immunoblotting analysis demonstrated a significantly decreased expression of type 1 AngII receptors (AT1R) in the entire hypothalamic tissue extract of LP rats at 12 days of age compared to age-matched NP offspring. Conversely, the expression of the type 2 AngII (AT2R) receptors in 12-day- and 16-week-old LP hypothalamus was significantly increased. The current data show the influence of central AngII administration on water consumption in a concentration-dependent fashion, but also demonstrate that the water intake response to AngII was strikingly attenuated in 16-week-old LP. These results may be related to decreased brain arginine vasopressin (AVP) expression appearing in maternal protein-restricted offspring. The present investigation shows an early decrease in fractional urinary sodium excretion in maternal protein-restricted offspring. The decreased fractional sodium excretion was accompanied by a fall in proximal...Continue Reading

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Citations

Sep 21, 2013·Life Sciences·Antonio Celso S Ramos-FilhoE Antunes
Dec 22, 2014·Neuroscience and Biobehavioral Reviews·Andre S MecawiJuan Arguelles
Mar 18, 2015·Korean journal of family medicine·Mohammad ShojaieArmin Akbarzadeh
Nov 13, 2014·Journal of Cellular and Molecular Medicine·Chun-Jian QiuTong-Huan Li
Aug 7, 2017·Current Hypertension Reports·Andrew C TiuVan Anthony M Villar
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Jan 27, 2019·International Journal of Molecular Sciences·Marilia Martins CavarianiRaquel Fantin Domeniconi

Methods Mentioned

BETA
electrophoresis

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