PMID: 8943100Dec 1, 1996Paper

Early chemotherapy and concurrent radio-chemotherapy in high grade glioma

Journal of Neuro-oncology
A A BrandesM V Fiorentino

Abstract

The poor results from treatment of high grade glioma prompted us to explore new protocols involving concurrent radio-chemotherapy. Our primary objective was to evaluate the feasibility of very early postoperative chemotherapy with BCNU, concurrent radio-chemotherapy with carboplatin and teniposide, and post-radiotherapy BCNU. Our secondary objectives were to evaluate time to progression, and overall survival. We treated 24 newly diagnosed patients (pts) with BCNU 150 mg/m2 seven days after surgery. Thirty days later, we started radiotherapy, 1.8 to 2 Gy/day for 5 days a week on limited fields up to 60 Gy, and concurrent chemotherapy with carboplatin 250 mg/m2 on days 1, 22, and 43, and teniposide 50 mg/m2 on days 1, 2, 3, 22, 23, 24, 43, 44 and 45. Two cycles of 150 mg/m2 BCNU were then given at 30 and 70 days, respectively, after the end of the radio-chemotherapy course. Therapy was then suspended, but if disease progression was evident, treatment was resumed with drugs that had not been previously employed. Surgical reintervention was not routinely considered. Following radio-chemotherapy treatment in the 24 pts evaluable for response, we observed partial remissions in 8 cases (33%) and stable disease in 12 (50%). Actuarial e...Continue Reading

Citations

Jul 26, 2003·Wiener klinische Wochenschrift·Barbara Fazeny-DörnerChristine Marosi
May 4, 1999·Cancer Investigation·I CokgorA H Friedman
Jan 30, 2002·Cancer·Johannes E A WolffJoachim Kühl
Oct 18, 2002·Expert Review of Anticancer Therapy·Umberto BassoAlba A Brandes
Jan 12, 2016·Current Neurology and Neuroscience Reports·Alba A BrandesEnrico Franceschi
May 20, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H S FriedmanL L Miller
Aug 21, 2008·Journal of Neuro-oncology·Camilo E FadulJeffrey J Olson

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