Early clinical experience with 5-aminolevulinic acid for the photodynamic therapy of upper tract urothelial tumors

The Journal of Urology
Raphaela WaidelichM Kriegmair

Abstract

Photodynamic therapy is effective in the treatment of superficial urothelial cancer of the bladder. We report our experience with photodynamic therapy for the treatment of upper urinary tract transitional cell carcinoma. Photodynamic therapy after oral administration of 5-aminolevulinic acid was performed in 4 patients with widespread superficial papillary tumors of the upper urinary tract. Complete remission occurred in 2 patients who remained free of local recurrence at 7 and 17 months of followup. In the other 2 patients residual tiny papillary tumors were found in the distal ureter after photodynamic therapy. These tumors were coagulated with neodymium:YAG laser irradiation. Both patients are disease-free at 24-month followup. Photodynamic therapy with 5-aminolevulinic acid is a minimally invasive approach for organ preserving treatment of multifocal superficial transitional cell carcinoma of the upper urinary tract.

References

Jan 1, 1992·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·T J Dougherty, S L Marcus
Jul 30, 1992·Journal of Photochemistry and Photobiology. B, Biology·J C Kennedy, R H Pottier
Jan 1, 1990·Lasers in Surgery and Medicine·T J DoughertyT S Mang
Jun 1, 1989·The Journal of Urology·J I HartyW Broghamer
Apr 1, 1989·The Journal of Urology·N T Schmeller, A G Hofstetter
Jan 1, 1993·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·J G McLeod
May 1, 1993·British Journal of Urology·P M WestonD M Wallace
Feb 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R RiesenbergM Kriegmair

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Citations

Mar 24, 2012·Urologic Oncology·M J BaderRaphaela Waidelich
Sep 11, 2012·Photodiagnosis and Photodynamic Therapy·G BozziniS Mordon
Aug 18, 2000·Photochemistry and Photobiology·R C KriegR Knuechel
Nov 2, 2007·International Journal of Cancer. Journal International Du Cancer·Manpreet BhattiMahendra P Deonarain
Mar 18, 2006·Photochemistry and Photobiology·Nicolas FotinosNorbert Lange
Nov 13, 2007·The Journal of Urology·Raj S PruthiEric M Wallen
Oct 9, 2019·Pharmaceuticals·Sara Sansaloni-PastorNorbert Lange
Nov 8, 2011·Lasers in Surgery and Medicine·Anette WeyergangKristian Berg
Mar 4, 2000·The Urologic Clinics of North America·M M Walther

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